Non-canonical pathway

Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

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The transcription factorNF-jB is activated in cellular stress responses. This requires rapid regulation of its function, which is accomplished, in part, by various modes of phos-phorylation. Even though diverseDNAbinding subunits of NF-jB proteins may transactivate fromdistinct recognition sequences, the differential regulation of transcription from the large number of NF-jB responsive sites in various gene promoters andenhancershasbeen incompletelyunderstood.

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