Báo cáo khoa học: Phosphorylation of NF-jB proteins by cyclic GMP-dependent kinase A noncanonical pathway to NF-jB activation
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The transcription factorNF-jB is activated in cellular stress responses. This requires rapid regulation of its function, which is accomplished, in part, by various modes of phos-phorylation. Even though diverseDNAbinding subunits of NF-jB proteins may transactivate fromdistinct recognition sequences, the differential regulation of transcription from the large number of NF-jB responsive sites in various gene promoters andenhancershasbeen incompletelyunderstood.
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