Overcoming resistance
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Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.
12p vishanshan 27-06-2024 2 1 Download
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Part 1 of ebook "Value chain marketing: A marketing strategy to overcome immediate customer innovation resistance" provides readers with contents including: Part I - Focus and scope; Part II - Conceptual and methodological foundation; Part III - Qualitative studies;...
146p giangmacvien 22-06-2024 1 1 Download
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Part 2 of ebook "Value chain marketing: A marketing strategy to overcome immediate customer innovation resistance" provides readers with contents including: Part IV - Computational modeling; Part V - Integrating findings; Appendix A – Details, pilot study; Appendix B – Details, case study; Appendix C – Details, agent-based simulation study;...
125p giangmacvien 22-06-2024 3 1 Download
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Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/carboplatin+bevacizumab a common chemotherapy regimen for stage IV non-squamous NSCLC; however, primary or acquired resistance to paclitaxel is gradually increasing, leading to treatment failure.
13p vikoch 27-06-2024 2 1 Download
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Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell typespecific transcriptomic changes over the clinical course of the disease using single-cell RNA sequencing (scRNA-seq).
21p vibransone 28-03-2024 3 2 Download
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Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy.
22p vioraclene 31-03-2024 2 2 Download
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Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.
322p duongthandue0501 28-02-2024 3 1 Download
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Part 1 book How to overcome the antibiotic crisis - Facts, challenges, technologies and future perspectives" includes content: tackling threats and future problems of multidrug resistant bacteria, emergence and spread of antimicrobial resistance - recent insights from bacterial population genomics, diagnostics and resistance profiling of bacterial pathogens, anti virulence strategies to target bacterial infections..... and other contents.
211p oursky06 17-10-2023 7 3 Download
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Recent reports suggested combining ramucirumab with epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKIs) to overcome EGFR resistance in non–small cell lung cancer (NSCLC).
8p visharma 20-10-2023 3 2 Download
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Glioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the expansion of glioblastoma stem cells (GSC), contributing to tumor relapse. Because of a deregulated sphingolipid metabolism, glioblastoma tissues contain high levels of the pro-survival sphingosine-1-phosphate and low levels of the pro-apoptotic ceramide.
23p vioracle 29-09-2023 3 2 Download
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In the current modern era, converting CH4 and CO2 into fuels and chemicals introduces a solution to several current pressing issues, such as limiting greenhouse gas emissions, overcoming the shortage of C resources, producing green fuels and chemicals, and realising carbon neutral cycles.
19p viberbers 09-08-2023 7 3 Download
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Therapeutic options are needed for metastatic melanoma refractory to therapies directed against programmed cell death-1. High-dose interleukin-2 has the potential to overcome programmed cell death-1 resistance.
5p vigamora 23-05-2023 6 2 Download
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Investigation of a recent rise of dual amantadineresistance mutations in the influenza A M2 sequence
The S31N amantadine-resistance mutation in the influenza A M2 sequence currently occurs more frequently in nature than the S31 wild type. Overcoming the resistance of the S31N mutation is the primary focus of M2 researchers who aim to develop novel antiviral therapies.
9p vinarcissa 21-03-2023 4 1 Download
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Organizational behavior: Lecture 38 provide students with knowledge about: rate of technological change; resistance to change; driving forces; overcoming resistance; minimizing resistance to change; managing organizational change; change management concept model;... Please refer to this lesson for details!
38p hanlamcoman 26-11-2022 8 3 Download
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Pregnancy is considered as a test for beta cell reserve. If there is a good function, insulin resistance will overcome. If not, gestational diabetes will occur. Insulin resistance (IR) present in normal pregnancy is required to provide nutrients to the growing fetus. There is a rapid increase of insulin in such an insulin resistant state.
5p viporsche 28-10-2022 7 2 Download
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Continued part 1, part 2 of ebook "Focus on gynecologic malignancies" provide readers with content about: hormonal and metabolic strategies to overcome insulin resistance and prevent endometrial cancer; management of endometrial cancer precursors in obese women; exercise and lifestyle interventions in gynecologic cancer survivors; physical activity as a risk factor for ovarian cancer; impact of obesity on surgical approaches to gynecologic malignancies;... Please refer to the ebook for details!
144p tieuduongchi 24-10-2022 5 3 Download
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Tyrosine kinase inhibitors (TKIs) are mainstays of cancer treatment. However, their clinical benefits are often constrained by acquired resistance. To overcome such outcomes, we have rationally engineered APG-2449 as a novel multikinase inhibitor that is highly potent against oncogenic alterations of anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 receptor tyrosine kinase (ROS1), and focal adhesion kinase (FAK).
15p vikolindagrabar 27-07-2022 6 2 Download
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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indicated by its low response rates and failure to prolong the progression-free survival (PFS).
9p viangelamerkel 27-07-2022 2 1 Download
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The explosive growth of genomic data provides an opportunity to make increased use of sequence variations for phenotype prediction. We have developed a prediction machine for quantitative phenotypes (WhoGEM) that overcomes some of the bottlenecks limiting the current methods.
20p vigalileogalilei 27-02-2022 8 1 Download
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Identification of genes whose basal mRNA expression predicts the sensitivity of tumor cells to cytotoxic treatments can play an important role in individualized cancer medicine. It enables detailed characterization of the mechanism of action of drugs. Furthermore, screening the expression of these genes in the tumor tissue may suggest the best course of chemotherapy or a combination of drugs to overcome drug resistance.
21p vialfrednobel 29-01-2022 11 0 Download