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P. jirovecii
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Pneumocystis jirovecii is responsible for Pneumocystis pneumonia (PCP), which occurs almost exclusively in immunocompromised individuals. Trimethoprim-sulfamethoxazole (TMP-SMZ) is regarded as the first-line treatment and prophylaxis for P. jirovecii infection, but the frequency of adverse reactions and newly emerged antibiotic resistance limit its use.
6p
vimaine2711
26-03-2021
13
1
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Pneumocystis jirovecii (P. jirovecii) is an opportunistic fungal pathogen and the role of its colonization in pulmonary diseases has become a popular focus in recent years. The aim of this study was to develop a modified loop-mediated isothermal amplification (LAMP) assay for detection of Pneumocystis jirovecii (P. jirovecii) DNA amongst non-HIV patients with various pulmonary diseases and use it to examine the prevalence and assess the association of P. jirovecii colonization with clinical characteristics of these diseases.
13p
vimaine2711
26-03-2021
11
2
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To investigate the molecular characteristics and genotype distribution of Pneumocystis jirovecii in HIV/AIDS patients who were admitted to the National Hospital for Tropical Diseases. Subjects and methods: Prospective and cross-sectional description. 31 HIV/AIDS patients infected with P. jirovecii and confirmed by bronchoscopy and realtime PCR from 01 - 2014 to 12 - 2017 were included for this study. Results and conclusions: Nucleotide analysis revealed that no nucleotide alteration occured in the loci β-TUB, CYB, DHFR, DHPS, whereas minor variable positions were observed in the SOD locus.
7p
caygaolon
31-10-2019
14
1
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Bài viết xác định đặc điểm phân tử và kiểu gen của chủng Pneumocystis jirovecii ở bệnh nhân HIV/AIDS mắc viêm phổi đang điều trị tại Bệnh viện Bệnh Nhiệt đới Trung ương. Đối tượng và phương pháp: nghiên cứu tiến cứu, mô tả cắt ngang 31 bệnh nhân HIV/AIDS mắc viêm phổi nhiễm P. jirovecii được khẳng định bằng nội soi phế quản và realtime PCR từ 01 - 2014 đến 12 - 2017. Kết quả và kết luận: đặc điểm phân tử của chủng P.
7p
caygaolon
31-10-2019
39
0
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