Particles used without

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Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells

The effects of protection of chylomicron remnants from oxidation on their uptake and induction of lipid accumula-tion in macrophages were investigated using chylomicron remnant-like particles (CRLPs) containing the lipophilic antioxidant drug, probucol, andmacrophages derived from thehumanmonocyte cell line,THP-1.The total lipidcontent of THP-1 macrophages was markedly higher (·2.2) after 48 h of incubation of THP-1 macrophages with CRLPs containing probucol (pCRLPs) when compared to CRLPs without probucol, and this was because of increases in tri-acylglycerol (·2.3) and cholesterol (·1.

11p dell39 03-04-2013 56 3 Download

Thermal Stability of RNA Phage Virus-Like Particles Displaying Foreign Peptides

Background: To be useful for genetic display of foreign peptides a viral coat protein must tolerate peptide insertions without major disruption of subunit folding and capsid assembly. The folding of the coat protein of RNA phage MS2 does not normally tolerate insertions in its AB-loop, but an engineered single-chain dimer readily accepts them as long as they are restricted to one of its two halves.

0p toshiba25 08-12-2011 46 3 Download