Personalised medicine

Part 1 book "Rang and Dale's pharmacology" includes content: Cell proliferation, apoptosis, repair and regeneration; cellular mechanisms; method and measurement in pharmacology; drug absorption and distribution; drug metabolism and elimination; pharmacokinetics; pharmacogenetics, pharmacogenomics and ‘personalised medicine’; chemical mediators and the autonomic nervous system,... and other contents.

357p dianmotminh03 03-06-2024 2 0   Download

Establishing the cancer type and site of origin is important in determining the most appropriate course of treatment for cancer patients. Patients with cancer of unknown primary, where the site of origin cannot be established from an examination of the metastatic cancer cells, typically have poor survival. Here, we evaluate the potential and limitations of utilising gene alteration data from tumour DNA to identify cancer types.

11p vioraclene 31-03-2024 6 2   Download

Personalised dietary modulation of the gut microbiota may be key to disease management. Current investigations provide a broad understanding of the impact of diet on the composition and activity of the gut microbiota, yet detailed knowledge in applying diet as an actionable tool remains limited.

14p vibransone 28-03-2024 6 2   Download

We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations.

15p vibransone 28-03-2024 2 1   Download

Part 1 book "Rang and Dale's pharmacology" includes content: How drugs act, how drugs act, how drugs act, how drugs act, cell proliferation, apoptosis, repair and regeneration, cellular mechanisms, method and measurement in pharmacology, absorption and distribution of drugs, drug metabolism and elimination, pharmacokinetics, individual variation, pharmacogenomics and personalised medicine,... and other contents.

413p muasambanhan05 22-01-2024 4 2   Download

Personalised medicine and targeted therapy have revolutionised cancer treatment. However, most patients develop drug resistance and relapse after showing an initial treatment response. Two theories have been postulated; either secondary resistance mutations develop de novo during therapy by mutagenesis or they are present in minor subclones prior to therapy.

14p vialabama2711 21-09-2020 7 1   Download

Bài giảng Y học cá nhân hóa (Personalised medicine) trình bày khái niệm về y học cá nhân hóa; cơ sở của y học cá nhân; y học cá nhân hóa trong bệnh tiểu đường; y học cá nhân hóa trong bệnh tim mạch; y học các nhân hóa trong ung thư.

6p kequaidan7 04-09-2020 52 2   Download

Patients with primary and metastatic liver malignancies represent a highly heterogeneous patient pool characterised by some of the shortest life expectancies amongst oncology patients. Investigation and better understanding of liver malignancies is an emerging field which requires high-quality multidisciplinary research and collaboration.

11p vinaypyidaw2711 26-08-2020 10 0   Download

The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit.

10p vikuala271 13-06-2020 11 1   Download

Overwhelming demand from developers slowed the Government’s approval process which in turn slowed development considerably. However, the banking industry has adjusted to the new federal regulatory requirements, improved their lending position by removing troubled loans and increasing capital and placed themselves in a position to loan once again. Banks have become more aggressive and competition for new loans is tremendous. Because of the strong apartment market, conventional financing for new communities is becoming more readily available.

5p connhobinh 07-12-2012 38 3   Download

Only recently have Indigenous Peoples in North America begun to revitalize traditions openly and without fear of persecution. We must remember that it is only since the 1970s that legal bans on healing/religious ceremonies such as the Sundance have been lifted. This Indigenous literature is often found outside of academia and within Native organizations and their resource libraries, research reports (founded either by government or community bodies) and Web sites such as American Indian Physicians Association, the World Health Organization and Pan American Health Organization.

252p quaivatdo 17-11-2012 50 2   Download

Integration of the patient electronic health record (EHR) with publicly accessible information creates new opportunities and challenges for clinical research and patient care. For example, one challenge is that the complexity of the information provided to the clinician must not impair the clinician’s ability to accurately and rapidly prescribe drugs that are safe and effective for a specific patient, and covered by the patient’s insurance provider.

9p thangbienthai 17-11-2012 54 3   Download

The sequencing of the human genome together with the development and implementation of new high throughput technologies (so called “omics”) are enhancing our knowledge on human health and disease and have already, and will continue, to provide a sound foundation for personalised medicine.

24p quynho77 14-11-2012 49 0   Download

Europe is facing multiple challenges in the health sector and in health research. In the health sector, ageing population, failures of blockbuster approaches, increasing costs of healthcare and concomitant cost containment for healthcare are just a few of the obstacles to face. In health research, there is a need to better understand the mechanisms of diseases, break barriers across disciplines, and translate research results into clinical practice. Personalised medicine is an emerging field that promises to bring radical changes in healthcare.

7p quynho77 14-11-2012 45 0   Download

The successful integration of omics-based personalised medicine into clinical practice does not only require the demonstration of its clinical utility and cost-effectiveness but also the development of processes so that the relevant information is available to the correct health practitioner at the appropriate time. This is particularly important as the routine availability of whole genome sequences becomes a reality. In conjunction with education, research in clinical bioinformatics needs to be undertaken as to how such vast data can be appropriately presented.

0p quynho77 14-11-2012 38 0   Download

Reliable gene-lifestyle interaction studies will yield important evidence for the shaping of personalised healthcare. Studies need statistical power with adequate environmental exposures and lifestyle heterogeneity to obtain reliable evidence on the interplay between nurture and nature. Europe has a historic strength in large epidemiological studies but technology development and implementation is needed to better ascertain environmental exposure and dietary heterogeneity.

16p quynho77 14-11-2012 47 3   Download

A quick win in personalised medicine could be in the area of rare inherited disorders, of which most are life-threatening or seriously debilitating. Currently, 6000-8000 rare inherited disorders are known and the genetic basis of around halve has been resolved. About a thousand are currently treatable and taken together all rare inherited disorders place a major burden on Europe’s health care systems.

19p quynho77 14-11-2012 58 0   Download

Genomics and other "omics” technologies have largely contributed to the identification and the development of biomarkers. Due to genetic causes of variability among individuals, genotyping and gene expression analysis are indeed key elements of the emergence of personalised medicine. However, genomic technologies have limitations (functional significance of genetic variants, false negatives, etc) and cannot encompass all approaches for the development of stratification biomarkers.

8p quynho77 14-11-2012 46 0   Download

The workshop "Stratification biomarkers in personalised medicine" that was held at the European Commission in Brussels on 10th and 11th June 2010 brought together experts from different fields and perspectives in order to stimulate an open discussion about the evolution of this rapidly expanding area, in which biomarkers are used to adapt therapies to the characteristics of patient populations.

37p quynho77 13-11-2012 57 2   Download

Despite advances in pharmacology, not all patients respond favourably to drugs. A proportion of patients under therapy don't benefit from their treatment or experience an adverse reaction to the medication. However, progress in the understanding of disease mechanisms and drug actions are opening opportunities to match therapies to patient populations, and thus pave the way towards a more personalised medicine.

0p quynho77 13-11-2012 37 0   Download