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Phase III
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Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic ablative radiotherapy (SABR) delivered in just 5-fractions. This study aims to evaluate the safety, efficacy, and non-inferiority of generalizable 2-fraction SABR compared to the current 5-fraction regimen.
10p
vishanshan
27-06-2024
1
1
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Part 1 of ebook "Ceramic materials: Science and engineering" provides readers with contents including: Part I - History and introduction; Part II - Materials; Part III - Tools; Part IV - Defects;...
316p
mothoiphong
28-06-2024
1
1
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Almost one third of cancer patients in the United States will develop brain metastases on an annual basis. Surgical resection is indicated in the setting of brain metastases for reasons, such as maximizing local control in select patients, decompression of mass effect, and/or tissue diagnosis.
8p
vikoch
27-06-2024
2
1
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Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). In this study, we aim to generate evidence regarding consolidation chemotherapy efficacy in patients with locally advanced, inoperable ESCC.
8p
vikoch
27-06-2024
2
1
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Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About 33~50% of the patients present with metastatic disease at diagnosis. TGCT survivors experience short- and long-term sequelae, including cancer-related fatigue (CRF).
15p
vikoch
27-06-2024
2
1
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Anus preservation has been a challenge in the treatment of patients with low rectal adenocarcinoma (within 5 cm from the anal verge) because it is difficult to spare the anus with its functioning sphincter complex under the safe margin of tumour resection.
8p
vikoch
27-06-2024
1
1
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Ebook "ERP: making it happen the implementers’ - Guide to success with enterprise resource planning" presents the following content: Chapter 1 enterprise resource planning, chapter 2 the implementation challenge, chapter 3 company-wide implementation—overview, chapter 4 software, chapter 5 getting ready, chapter 6 project launch, chapter 7 initial education, chapter 8 sales & operations planning, chapter 9 process definition, chapter 10 data integrity, chapter 11 going on the air—basic erp (phase I), chapter 12 going on the air-supply chain integration (phase II), chapter 13 quick-slice erp...
385p
zizaybay1103
29-05-2024
3
2
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Based on promising phase II data, the histone deacetylase inhibitor entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.
14p
vibransone
28-03-2024
5
2
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Ebook "Material designs and new physical properties in MX- and MMX-chain compounds" is the first book to comprehensively address the recent developments in both the experimental and theoretical aspects of quasi-one-dimensional halogen-bridged mono- (MX) and binuclear metal (MMX) chain complexes of Pt, Pd and Ni. These complexes have one-dimensional electronic structures, which cause the various physical properties as well as electronic structures.
275p
coduathanh1122
27-03-2024
2
1
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Part 2 book "Engineering and chemical thermodynamics" includes content: Phase equilibria I - Problem formulation, phase equilibria II - Fugacity, phase equilibria III - applications, chemical reaction equilibria.
378p
muasambanhan09
12-03-2024
0
0
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Ebook "NMR in biological systems: From molecules to humans" caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.
552p
tachieuhoa
28-01-2024
8
2
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Ebook Advanced persistent threat hacking: The art and science of hacking any organization – Part 2 includes contents: Chapter 6 spear social engineering, chapter 7 phase III: remote targeting, chapter 8 spear phishing with hardware trojans, chapter 9 physical infiltration, chapter 10 APT software backdoors.
348p
haojiubujain010
14-12-2023
4
1
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Postoperative stereotactic radiosurgery (SRS) is a standard management option for patients with resected brain metastases. Preoperative SRS may have certain advantages compared to postoperative SRS, including less uncertainty in delineation of the intact tumor compared to the postoperative resection cavity, reduced rate of leptomeningeal dissemination postoperatively, and a lower risk of radiation necrosis.
8p
vileonardodavinci
23-12-2023
4
2
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This study aims to systematically validate the performance of surrogate endpoints in phase II and III clinical trials for NSCLC patients under various trial settings. A literature search retrieved all registered phase II and III trials of NSCLC patients in which OS, with at least one of ORR and PFS, were reported. Associations between surrogate and true endpoints were assessed on two levels.
13p
vialfrednobel
23-12-2023
6
3
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First-line treatment of nonsquamous non–small cell lung cancer (NSCLC) has undergone a paradigm shift to platinum combination therapy together with immune checkpoint inhibitors (ICIs). However, phase III studies of combinations of cytotoxic chemotherapy and ICIs have included only patients with maintained organ function, not those with renal impairment.
5p
vialfrednobel
23-12-2023
9
3
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Radiotherapy of head-and-neck cancer (SCCHN) is often associated with acute toxicity. In a previous trial, daily reminders by staff members to perform skin care resulted in less dermatitis. This randomized trial investigated whether a mobile application can replace these reminders.
9p
vialfrednobel
23-12-2023
4
3
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Efforts have been made to investigate the role of salvage radiotherapy (RT) in treating recurrent ovarian cancer (ROC). Stereotactic ablative radiation therapy (SABR) is a state-of-the-art therapy that uses intensity modulation to increase the fractional dose, decrease the number of fractions, and target tumors with high precision.
7p
vialfrednobel
23-12-2023
4
4
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Laparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks, such as motion restriction and difficulties in spatial perception.
7p
visharma
20-10-2023
5
4
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Immunotherapy (IO) has become a standard of care for treating various types of metastatic cancers and has significantly improved clinical outcome. With the exception of metastatic melanoma in complete response for which treatment can be stopped at 6 months, these treatments are currently administered until either disease pro‑ gression for some IO, 2 years for others, or unacceptable toxicity.
10p
visharma
20-10-2023
6
3
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Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challenging due to comorbidities and reduced performance status.
10p
vioracle
29-09-2023
6
3
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