Phosphoribosyltransferase
-
Hypoxanthine guanine phosphoribosyltransferases (HGPRTs) catalyze the conversion of 6-oxopurine bases to their respective nucleotides, the phos-phoribosyl group being derived from phosphoribosyl pyrophosphate.
0p 
awards
06-04-2013
37
2
Download
-
Theuppgene, encoding uracil phosphoribosyltransferase (UPRTase) from the thermoacidophilic archaeon Sulfolobus solfataricus, was cloned and expressed inEscherichia coli. The enzyme was purified to homogeneity. It behaved as a tetramer in solution and showed optimal activity at pH 5.5 when assayed at 60C. Enzyme activity was strongly stimulated by GTP and inhibited by CTP.
14p awards
06-04-2013
24
5
Download
-
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a potential target for structure-based inhibitor design for the treatment of parasitic dis-eases. We created point mutants of Thermoanaerobacter tengcongensis HGPRT and tested their activities to identify side chains that were impor-tant for function.
8p media19
04-03-2013
25
1
Download
CHỦ ĐỀ BẠN MUỐN TÌM
