Báo cáo khoa học: Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant ) insights into inhibitor design
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a potential target for structure-based inhibitor design for the treatment of parasitic dis-eases. We created point mutants of Thermoanaerobacter tengcongensis HGPRT and tested their activities to identify side chains that were impor-tant for function.
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