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Plasma concentration
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Congenital factor VII deficiency is a rare disease. Inhibitor development in congenital factor VII deficiency is an extreme rare phenomen, as the main challenge of replacement therapy by a high rate of life-threatening bleeding, that renders replacemrnt therapy less effective.
4p
viwalton
29-06-2024
1
1
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p
vikoch
27-06-2024
1
1
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The plasma renin concentration (PRC) assay directly measures the concentration of active renin in the plasma, independent of the amount of angiotensinogen. The aim of this study was to determine the correlation between PRC and PRA, PAC to PRC and PAC to PRA ratios.
9p
vilarry
12-03-2024
4
2
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Metformin-induced lactic acidosis with acute kidney injury is rare but well known. Here we report a case of a Japanese patient taking metformin who experienced severe acute renal failure accompanied with significantly elevated metformin plasma concentrations and signs of lactic acidosis.
7p
vitiki
30-01-2024
4
2
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Methotrexate (MTX) is a chemotherapy and immunosuppressive agent widely used to treat cancer, autoimmune diseases in children and adult patients, and ectopic pregnancy. However, MTX is highly toxic to the liver, kidney, and nervous system. This study aimed to quantify the concentration of MTX in human plasma using high-performance liquid chromatography (HPLC).
6p
vikissinger
21-12-2023
1
1
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To unravel how the integrity of nuclear and mitochondrial circulating cell-free DNA (cfDNA) contributes to its plasma quantity in colorectal cancer (CRC) patients. Methods CfDNA from plasma samples of 80 CRC patients stratified by tumour stage and 50 healthy individuals were extracted. Total cfDNA concentration was determined and equal template concentrations (ETC) were analyzed by quantitative real-time PCR (qPCR) resulting in small and long fragments of KRAS, Alu and MTCO3.
14p
vischultz
20-10-2023
4
1
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Đề tài được tiến hành với mục tiêu xác nhận giá trị sử dụng xét nghiệm hoạt độ renin huyết tương (Plasma renin activity - PRA), định lượng nồng độ aldosterone huyết tương (Plasma aldosterone concentration - PAC), định lượng nồng độ renin huyết tương (Plasma renin concentration - PRC) trên máy Maglumi 800.
8p
vioracle
26-09-2023
9
1
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The status of chromium as an essential nutrient is an ongoing debate despite its widespread use as supplement. Chromium supplement has been reported to improve glucose tolerance, insulin action and promote weight loss. This study examined the effect of given high concentrations of glucose D to chromium picolinate pretreated rats.
4p
viisac
23-09-2023
6
1
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Compare to other documents, our study was for the first time validated the quality criteria of ICP-MS for analyzing nineteen metal levels in wastewater samples. The application of this method was then tested by analyzing nineteen metal levels in twenty-three wastewater samples in the Tham Luong Canal in Ho Chi Minh City. Based on these results, the correlation of the concentration of these metals in wastewater samples was determined.
7p
viengels
25-08-2023
7
3
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Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits.
8p
vinarcissa
21-03-2023
9
1
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To investigate plasma erythropoietin (EPO) concentration and its relationship with some characteristics in type 2 diabetic patients (T2DM) with chronic kidney injury (CKI). Subjects and methods: A cross-sectional descriptive study on 219 subjects, including 129 patients with type 2 diabetes with chronic kidney injury, 51 patients with diabetes without CKI as a disease control group, and 39 healthy people as a normal control group. All subjects had their plasma EPO levels quantified by ELISA.
9p
vilucius
03-03-2023
5
1
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Liquid Chromatography tandem mass spectrometry (LC-MS/MS) is the gold-standard approach for androgen analysis in biological fluids, superseding immunoassays in selectivity, particularly at low concentrations. While LC-MS/MS is established for analysis of testosterone and androstenedione, 5αdihydrotestosterone (DHT) presents greater analytical challenges.
12p
viginny
23-12-2022
6
3
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Due to the increasing number of therapeutic monoclonal antibodies (mAbs) used in the clinic, there is an increasing need for robust analytical methods to quantify total mAb concentrations in human plasma for clinical studies and therapeutic drug monitoring. We developed an easy, rapid, and robust sample preparation method for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.
10p
viginny
23-12-2022
8
3
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To assess the normal levels of free fetal DNA in maternal plasma through pregnancy compared with those in pregnancies complicated with placental dysfunction manifested by preeclampsia of Vietnamese pregnant women.
9p
viangelamerkel
18-07-2022
6
2
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To investigate the relationship between plasma Hcy concentration and some ophthalmic and renal complications in patients with T2DM. Subjects and methods: 395 patients with type 2 diabetes treated as inpatients at the National Hospital of Endocrinology who were clinically examined for their organs and performed basic tests to diagnose and assess their disease status.
9p
viangelamerkel
18-07-2022
9
4
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Enhanced bleeding remains a serious problem after cardiac surgery, and fibrinolysis is often involved. We speculate that lower plasma concentrations of plasminogen activator inhibitor – 1 (PAI-1) preoperatively and tissue plasminogen activator/PAI-1 (t-PA/PAI-1) complex postoperatively might predispose for enhanced fibrinolysis and increased postoperative bleeding.
7p
viisaacnewton
26-04-2022
14
1
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Midazolam is commonly used as a pre-anesthesia anxiolytic. Its elimination may not be fast enough for short procedures. In orally premedicated patients we obtained midazolam plasma concentrations at the end of surgical procedures and compared those to concentrations at anesthesia induction.
6p
viottohahn
30-03-2022
6
1
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Epidural administration of morphine has been shown to be an effective analgesic strategy in horses; however, the possible occurrence of side effects limits its usage. In order to decrease their frequency, it is important to target the minimal effective plasma concentration and avoid overdosing.
5p
vigalileogalilei
28-02-2022
10
1
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Platelets undergo structural, biochemical and functional alterations when stored, and platelet storage lesions reduce platelet function and half-life after transfusion. The objective of this study was to evaluate stored canine platelet concentrates with platelet aggregation, flow cytometry and biochemistry assays.
7p
vigalileogalilei
28-02-2022
18
1
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The objective of this study was to determine the renal clearance of flunixin and meloxicam in pigs and compare plasma and urine concentrations and tissue residues. Urine clearance is important for livestock show animals where urine is routinely tested for these drugs.
10p
vigandhi
23-02-2022
12
2
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