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PPAR gamma
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Type 2 diabetes mellitus is a serious public health problem in the world and its treatment is still a major therapy challenge. Thiazolidinediones (TZDs) are a class of antidiabetic drugs that are used widely to increase insulin sensitivity by activating PeroxisomeProliferator-Activated-Receptor-gamma (PPARγ). Activated PPARγ makes critical alterations in the transcription of genes that regulate glucose and lipid metabolism. However, TZDs have side effects, such as weight gain, edema, congestive heart failure, and bone fracture.
8p
cothumenhmong9
07-01-2021
11
1
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Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily. PPARγ is essential in adipocyte differentiation from precursor cells. Its antitumorigenic effects are reported in certain malignancies; however, its effects in liposarcoma are unclear.
8p
vinaypyidaw2711
26-08-2020
12
2
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Cancer stem cells (CSC) are characterized by deregulated self-renewal, tumorigenicity, metastatic potential, aberrant stemness signaling pathways, resistance to conventional therapy, and the ability to give rise to a progeny of proliferating cells that constitute the bulk of tumors.
12p
vimanila2711
25-06-2020
5
1
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The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. Commitment to osteogenesis is associated with activation of osteoblast-related signal transduction, whereas inactivation of this signal transduction favors adipogenesis.
13p
viwashington2711
04-12-2019
10
1
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Whether pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma agonist, increases the risk of developing bladder cancer has been debated for several years. The aim of this study was to investigate the in vitro effects of PIO on normal urothelial transitional epithelium (NUTE) cells and bladder cancer (J82) cells to further evaluate the risk.
10p
vinasaki2711
12-11-2019
14
1
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