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Preclinical pharmacology
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Ebook "Progress in the chemistry of organic natural products (Volume 102)" provides readers with contents including: ingenane diterpenoids; the Laurencia paradox - an endless source of chemodiversity;...
258p
tracanhphuonghoa1007
22-04-2024
6
3
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Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs underscores the need for better, more predictive in vitro safety screens to be deployed early in the drug discovery process.
12p
vienzym2711
03-04-2020
10
2
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Filgrastim or methionyl-granulocyte colony-stimulating factor (Met-G-CSF), is a recombinant therapeutic protein widely used to treat severe neutropenia caused by myelosuppressive drugs in patients with nonmyeloid malignancies.
13p
vienzym2711
03-04-2020
6
1
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Pueraria candollei var. mirifica is a medicinal plant that is promoted as a “Champion Product” by the Government of Thailand. This plant has been reported to relieve postmenopausal symptoms, prevent and reverse bone loss, inhibit the growth of breast cancer, and alleviate cardiovascular diseases in preclinical and clinical studies.
9p
vimax2711
30-03-2020
10
0
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Proarrhythmia assessment is one of the major concerns for regulatory bodies and pharmaceutical industry. ICH guidelines recommending preclinical tests have been established in attempt to eliminate the risk of drug-induced arrhythmias.
15p
vienzym2711
30-03-2020
12
1
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Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells.
11p
vimax2711
30-03-2020
10
1
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While researching this book, I came across a letter in the journal Nature asking for caution in the current trend for the use of humorous nomenclature for newly discovered genes1, the author referring to the tumour suppressor gene Pokemon, which I have briefly described in Chapter 4.
349p
hyperion75
18-01-2013
44
5
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein...
11p
thulanh27
12-12-2011
36
5
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Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...
9p
bigbaby87
03-09-2010
115
21
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