Preventive medicine

The orientation activity at the beginning of the school year is one of the important sessions for medical students, especially first-year students. Well-oriented medical students will contribute to training appropriate future medical human resources, especially in preventive medicine and public health with the motto that prevention is better than cure. To describe career orientation and feedback on the first-year orientation activities of medical students at the School of Preventive Medicine and Public Health in 2022.

11p vihatake 06-01-2025 0 0   Download

Study objectives: To describe the current status and some factors related to hearing loss among the Armored Army soldiers in 2017; to evaluate the effectiveness of Mg-B6 supplementation in preventing hearing loss among the soldiers of Armored Tank Army in 2018.

30p badbuddy10 21-04-2022 22 2   Download

The objectives were: To describe the situation of HIV infection and risk behaviours of infection among injecting drug user in three provinces: Hoa Binh, Bac Kan, Tuyen Quang (2009-2010). To evaluate the effectiveness of comprehensive intervention model to prevent HIV transmission among injecting drug users (2011-2013).

28p petsematary 02-06-2021 33 4   Download

Describing the current situation of malaria and related factors in malaria area with changing emigration in Binh Phuoc and Gia Lai in 2016. Evaluating the efficiency of several methods for strengthening the malaria prevention in areas with changing emigration.

27p gaocaolon7 18-09-2020 69 2   Download

Understanding some risk factors for lower extremity DVT in the first time in patients treated at the intensive care unit of the Bach Mai hospital and the Friendship hospital. Review the results of lower extremity DVT prevention by low molecular weight heparin (Enoxaparin) in the above patient groups.

30p angicungduoc6 21-07-2020 36 4   Download

The amyloid protein precursor (APP) was incorporated into liposomes or phospholipid monolayers. APP insertion into liposomes required neutral lipids, such as L-a-phosphatidylcholine, in the target membrane. It was prevented in vesicles containing L-a-phosphatidylserine. The insertion was enhanced in acidic solutions, suggesting that it is modulated by specific charge/charge interactions. Surfaceactive properties and behaviour of APP were characterized during insertion of the protein in monomolecular films of L-a-phosphatidylcholine, L-a-phosphatidylethanolamine or L-a-phosphatidylserine. ...

9p research12 01-06-2013 42 4   Download

Department of Medical Chemistry, Kochi Medical School, Nankoku, Japan; 2Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan; 3Department of Anatomy and Cell Biology, Kochi Medical School, Nankoku, Japan We previously generated mice lacking aromatase activity by targeted disruption of Cyp19 (ArKO mice), and reported phenotypes of the female mice, showing hemorrhage formation and follicular depletion in the ovary, diminution in uterine size, and bone loss...

9p research12 01-06-2013 42 4   Download

A series of chimeric receptors was generated between the epidermal growth factor (EGF) receptor, ErbB-1, and its homologue, ErbB-4, to investigate the roles of the extracellular domains (I–IV) in the ligand specificities. As compared with ErbB-1 and the chimeras with both domains I and III of ErbB-1, the chimeras with only one of these domains exhibited reduced binding of 125I-labeled EGF. Particularly, the contribution of domain III was appreciably larger than that of domain I of ErbB-1 in 125I-labeled EGF binding.

7p research12 01-06-2013 48 5   Download

Hsp105aisoneof themajormammalianheat shockproteins that belongs to the HSP105/110 family, and is expressed at especially high levels in the brain as compared with other tissues in mammals. Previously, we showed that Hsp105a prevents stress-induced apoptosis in neuronal PC12 cells, and is a novel anti-apoptotic neuroprotective factor in the mammalian brain.

9p research12 23-04-2013 42 1   Download

Signal sequences often containa-helix-destabilizing amino acids within the hydrophobic core. In the precursor of the Escherichia coliouter-membrane protein PhoE,the glycine residue at position)10 (Gly )10 ) is thought to be responsible for the break in the a-helix. Previously,we showed that substitution of Gly )10 bya-helix-promoting residues (Ala, Cys or Leu) reduced the proton-motive force dependency of the translocation of the precursor,but the actual role of the helix breaker remained obscure. ...

8p tumor12 22-04-2013 34 3   Download

The oxidant function of pro-apoptotic protein Bax was investigated through heterologous expression in yeast. Direct measurements of fatty acid content show that Bax-expression induces oxidation of mitochondrial lipids. This effect is prevented by the coexpression of Bcl-xL. The oxi-dation actually could be followed on isolated mitochondria as respiration-induced peroxidation of polyunsaturatedcis-parinaric acid and on whole cells as the increase in the amount of thiobarbituric acid-reactiveproducts. ...

11p tumor12 22-04-2013 38 2   Download

Phosphorylation of RNA polymerase II’s largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism. Numerous enzymes, including cell cycle-dependent kinases and TFIIF-dependent phosphatases tar-get the CTD. However, the repetitive nature of the CTD prevents determination of phosphorylated sites by conven-tional biochemistry methods. Fortunately, a panel of monoclonal antibodies is available that distinguishes between phosphorylated isoforms of RNA polymerase II’s (RNAP II) largest subunit....

12p tumor12 20-04-2013 49 2   Download

The transcription patterns of 64 linear double stranded DNA templates obtained with T7 RNA polymerase were investigated. These templates consisted of 17 nucleotide-long sequences under the control of the minimal bac-teriophage T7 promoter and represented all possible combinations of nucleotides at positions +8, +10 and +11.

8p tumor12 20-04-2013 33 5   Download

Functional cooperationbetween integrins andgrowth factor receptors has been reported for several systems, oneofwhich is the modulation of insulin signaling by avb3 integrin. Plasminogen activator inhibitor type-1 (PAI-1), competes withavb3 integrin for vitronectin (VN) binding. Here we report that PAI-1, in a VN-dependent manner, prevents the cooperation of avb3 integrin with insulin signaling in NIH3T3 fibroblasts, resulting in a decrease in insulin-induced protein kinase B (PKB) phosphorylation, vascular endothelial growth factor (VEGF) expression and cell migration. ...

8p tumor12 20-04-2013 36 3   Download

The transcription factor hypoxia inducible factora-subunit (HIFa)is pivotal in the cellular response to the stress of hypoxia. Post-translational modification of HIFa by hydroxylase enzymes has recently been identified as a key
oxygen sensing mechanism within the cell. The absence of the substrate oxygen prevents the hydroxylases from modi-fying HIFaduring hypoxia and allows dramatic up-regula-tion of both HIFaprotein stability and transcriptional activation capability.

8p tumor12 20-04-2013 28 2   Download

Short strands of tandem hexameric repeats known as telomeres cap the ends of linear chromosomes.These repeats protect chromosomes from degradation and prevent chro-mosomal end-joining, a phenomenon that could occur due to the end-replicationproblem.Telomeres aremaintainedby the activity of the enzyme telomerase.The total number of telomeric repeats at the terminal end of a chromosome determines the telomere length, which in addition to its importance in chromosomal stabilization is a useful indica-tor of telomerase activity in normal and malignant tissues....

15p tumor12 20-04-2013 34 3   Download

Antioxidant protein 2 (AOP2) is a member of a family of thiol-specific antioxidants, recently renamedperoxiredoxins, that evolvedas part of anelaborate systemtocounteract and control detrimental effects of oxygen radicals. AOP2 is found in endothelial cells, erythrocytes, monocytes, T andB cells, but not in granulocytes. AOP2 was found solely in the cytoplasm and was not associated with the nuclear or membrane fractions; neither was it detectable in plasma.

8p tumor12 20-04-2013 34 2   Download

It is well known that activated Factor XII (FXIIa) and kallikrein are rapidly inactivated in plasma as a result of reaction with endogenous inhibitors. The purpose of this may be to prevent uncontrolled deleterious spreading and activation of target zymogens. Both FXII and the complex plasma prekallikrein/high molecular mass kininogen become activated when they bind, in a Zn 2+ -dependent manner, to receptors on human umbilical vein endothelial cells (HUVEC).

8p tumor12 20-04-2013 30 2   Download

The selective manipulation of the expression and replica-tion of mitochondrial DNA (mtDNA) within mammalian cells has proven difficult. In progressing towards this goal we synthesized a novel mitochondria-targeted DNA-alkylating reagent. The active alkylating moiety [(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c] [1,4]benzodiazepin-5-one (DC-81)], irreversibly alkylates guanine bases in DNA (with a preference for AGA tri-plets), preventing its expression and replication.

10p fptmusic 16-04-2013 33 4   Download

Farnesol is a catabolite of the cholesterol biosynthetic pathway that prefer-entially causes apoptosis in tumorigenic cells. Phosphatidylcholine (PC), phosphatidic acid (PA), and diacylglycerol (DAG) were able to prevent induction of apoptosis by farnesol. Primary alcohol inhibition of PC cata-bolism by phospholipase D augmented farnesol-induced apoptosis. Exogen-ous PC was unable to prevent the increase in farnesol-induced apoptosis by primary alcohols, whereas DAG was protective.

8p fptmusic 12-04-2013 35 2   Download