Primary determinant
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p vishanshan 27-06-2024 2 1 Download
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KRAS is the undisputed champion of oncogenes, and despite its prominent role in oncogenesis as mutated gene, KRAS mutation appears infrequent in gliomas. Nevertheless, gliomas are considered KRAS-driven cancers due to its essential role in mouse malignant gliomagenesis. Glioblastoma is the most lethal primary brain tumor, often associated with disturbed RAS signaling.
11p vishanshan 27-06-2024 1 1 Download
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Despite efforts to enhance the quality of medication prescribing in outpatient settings, potentially inappropriate prescribing remains common, particularly in unscheduled settings where patients can present with infectious and pain-related complaints. Two of the most commonly prescribed medication classes in outpatient settings with frequent rates of potentially inappropriate prescribing include antibiotics and nonsteroidal anti-infammatory drugs (NSAIDs).
12p vishanshan 27-06-2024 1 1 Download
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Emergency departments (ED) worldwide have to cope with rising patient numbers. Low-acuity consulters who could receive a more suitable treatment in primary care (PC) increase caseloads, and lack of PC attachment has been discussed as a determinant. This qualitative study explores factors that contribute to nonutilization of general practitioner (GP) care among patients with no current attachment to a GP.
10p vishanshan 27-06-2024 2 1 Download
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The primary purpose of this study is to compare Capital Asset Pricing Model with Arbitration Pricing Theory by considering the supply chain strategy. Another objective of this study is to determine the effect of Capital Asset Pricing Model (CAPM) and Arbitration Pricing Theory (APT) on excess returns and to determine the best asset pricing model in terms of ability to explain the estimation of excess return. This study examines the effect of variables in asset pricing models and compares the ability of asset pricing models in explaining excess return.
8p longtimenosee10 26-04-2024 2 1 Download
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The study aims to determine the technical efficiency and factors affecting the technical efficiency of lettuce farmers in Dalat City. The study’s primary data were collected by surveying structured questionnaires from 100 lettuce farmers in Dalat City.
13p viohoyo 25-04-2024 2 1 Download
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The aim of this study is to determine the problems, the solutions and the suggestions of the school principals and teachers towards the Syrian refugee students in the primary schools in Turkey. The research group of the study included four school principals and six teachers.
12p viarnault 25-04-2024 2 1 Download
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This research aims to complete Turkish adaptation, validity and reliability studies for the Math and Me Survey developed by Adelson and McCoach for use in determining the students’ attitudes towards mathematics in the transition from primary school to middle school.
8p viarnault 25-04-2024 3 1 Download
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The purpose of this study is to determine whether or not teachers’ lifelong learning tendencies vary by gender, professional field, educational level of service, professional seniority, and frequency of reading a book, magazine, and newspaper. The study employs a descriptive research model.
13p viarnault 25-04-2024 1 1 Download
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The aim of this research was to verify the feasibility of this approach for much younger students in primary school by evaluating the students’ progress in the subject S&T, identifying the differences in individual progress in relation to students’ general learning success, and determining students’ opinions about the approach and where no desired progress has been made.
14p viarnault 25-04-2024 2 1 Download
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The primary purpose of this research was to determine the effect of principal instructional leadership behavior on several determinants: Organizational commitment, efficacy, and teacher satisfaction through school health. Five instruments that had been used are the principal instructional management rating scale (PIMRS); organizational health inventory for elementary schools (OHIE); online course questionnaire (OCQ).
12p viarnault 25-04-2024 5 1 Download
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The formed primary level and dynamic and sustainable development of technological competence provides quality management of teaching activities, increases the efficiency of the educational process, accelerates the achievement of pedagogical goals. Delphi expert assessment technique is increasingly used in the paradigm of pedagogy. Due to the set of advantages and objectivity of assessments, it has become the dominant method of this study.
15p viarnault 25-04-2024 4 1 Download
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In this article we present research on Slovenian primary school teachers' opinion about the interdisciplinary approach between fine art and science education. With the help of questionnaires, interviews, and analysis of lesson plans, we determined how primary school teachers use this type of interdisciplinary approach, how often and what their views are.
9p viarnault 25-04-2024 2 1 Download
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The purpose of this study was to explore the factor structure of a measurement and to evaluate its internal reliability. Overall, 525 math-majoring elementary school teachers volunteered to participate in this study by answering online survey questions via Google Form.
11p viarnault 25-04-2024 1 1 Download
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The present paper provides a case study of rice farmers in the Muda granary area, which covers the states of Kedah and Perlis, using primary data to identify the factors on the adoption of PEP among farmers. The research findings indicate that the key factors determining the farmers’ adoption of the PEP are age, secondary jobs, effective communication with the extension agency, increased rice yield, lower operating cost, lower working time in the fields, and support services, such as assistance, incentives, and facilities from the government.
8p longtimenosee09 08-04-2024 4 1 Download
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Establishing the cancer type and site of origin is important in determining the most appropriate course of treatment for cancer patients. Patients with cancer of unknown primary, where the site of origin cannot be established from an examination of the metastatic cancer cells, typically have poor survival. Here, we evaluate the potential and limitations of utilising gene alteration data from tumour DNA to identify cancer types.
11p vioraclene 31-03-2024 6 2 Download
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Ebook "Deterministic kinetics in chemistry and systems biology: The dynamics of complex reaction networks" gives a concise overview of the mathematical foundations of kinetics used in chemistry and systems biology. The analytical and numerical methods used to solve complex rate equations with the widely used deterministic approach will be described, with primary focus on practical aspects important in designing experimental studies and the evaluation of data.
142p tudohanhtau1006 29-03-2024 9 1 Download
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The study was aimed at analyzing determinants of smallholders’ beef cattle market participation and quantity supplied to the market in Toke Kutaye and Bako Tibe Districts, West Shewa Zone, Oromia National Regional State, Ethiopia. The primary data for this study were collected from 376 sampled household producers by using interview schedule, site visit and personal observation. Data analysis was made using descriptive and inferential statistics and heckman two-step selection model.
12p longtimenosee06 27-03-2024 2 1 Download
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p viellison 28-03-2024 3 2 Download
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The primary research aim of this project is to provide a methodology for the measurement of OPFR chemicals in fish samples. This will be achieved by enhancing the QuEChERS technique, with a particular focus on improving the conditions for solvent vaporization and validating the analytical method.
7p viellison 28-03-2024 2 1 Download