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  • A Bayesian approach with frequentist validity has been developed to support inferences derived from a BLevel A^ in vivo-in vitro correlation (IVIVC). Irrespective of whether the in vivo data reflect in vivo dissolution or absorption, the IVIVC is typically assessed using a linear regression model. Confidence intervals are generally used to describe the uncertainty around the model. While the confidence intervals can describe population-level variability, it does not address the individual-level variability.

    pdf16p caothientrangnguyen 09-05-2020 35 2   Download

  • Simulation allows the repeated solution of an evaluation model. Each solution randomly selects values from predetermined probability distributions. All solutions are summarized into an overall distribution of NPV values. This distribution shows management how risky the project is.

    ppt12p muaxuan102 21-02-2013 51 5   Download

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