Promoter binding protein
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Resveratrol has demonstrated its ability to regulate BRCA1 gene expression in breast cancer cells, and previous studies have established the binding of MBD proteins to BRCA1 gene promoter regions. The aimed to evaluate the impact of MBD proteins on the regulation of BRCA1, BRCA2, and p16 genes and their consequential effects on breast cancer cells.
18p vishanshan 27-06-2024 2 1 Download
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DNA-Damaged Binding protein 2 (DDB2) is a protein involved in the early step of Nucleotide Excision Repair. Recently, it has been reported that DDB2 is involved in epithelial-to-mesenchymal transition (EMT), key process in tumour invasiveness and metastasis formation. However, its role is not completely known.
16p vishanshan 27-06-2024 1 1 Download
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MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor.
13p visharma 20-10-2023 8 2 Download
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ADP-ribosylation factor-like protein 4 C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4C protein promotes cell motility, invasion, and proliferation.
6p visharma 20-10-2023 4 2 Download
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In tissue engineering, coating biomaterial’s surface with extracellular matrix (ECM) proteins can promote many biological activities, including cellular responses, wound healing, and rejection reduction. Several interactions occur upon binding proteins onto the surfaces, leading to changes in the protein structural conformation, directly affecting the cell-host interactions. Therefore, this study investigates the impacts of surfaces’ wettability on protein conformation.
10p vimulcahy 18-09-2023 6 3 Download
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Studies on nanoparticle-protein interaction have also not been studied. This would give information on ratio influence on the structural alteration of EGCg in EGCg-AuNPs and its functionality in vivo. Herein, the optimisation of EGCg-AuNPs will be determined with a large pool of stoichiometric synthesises of gold and EGCg. These optimised EGCg-AuNPs would then be studied with bovine serum albumin (BSA) for protein interactions, binding and thermodynamics.
177p runthenight07 01-03-2023 5 2 Download
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Head and neck squamous cell carcinoma (HNSCC) is one severe malignancy driven by complex cellular and signalling mechanisms. However, the roles of circular RNAs (circRNAs) in HNSCC’s development remains poorly understood.
16p viangelamerkel 27-07-2022 5 1 Download
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Vi khuẩn Xanthomonas oryzae pv. oryzae (Xoo) gây nên bệnh bạc lá lúa thông qua cơ chế chính là tiết ra các protein TALE (Transcription activator-like effector) có khả năng kiểm soát hoạt động một số gen của tế bào chủ bằng cách liên kết với các trình tự EBE (Effector-binding elements) trên vùng promoter và hoạt hóa biểu hiện gen.
8p viindranooyi 09-05-2022 29 3 Download
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TNF is a pleiotropic cytokine and shows its biological function by binding to its receptors called TNFR1 and TNFR2. While TNFR1 induces apoptosis by activation of caspase-8 via the “death domain”, it also activates IKKα/β, MKK3/6, MKK4/7 by activation of TAK1. Although the TNFR1 signaling pathway is known by in large, it is not known how AKT and MAPKs p38, ERK1/2, and JNK1/2 are activated.
9p thiencuuchu 27-11-2021 5 1 Download
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SQUAMOSA promoter binding proteins (SBPs) genes encode a family of plant-specific transcription factors involved in various growth and development processes, including flower and fruit development, leaf initiation, phase transition, and embryonic development. The SBP gene family has been identified and characterized in many species, but no systematic analysis of the SBP gene family has been carried out in sugarcane.
16p vilarryellison 29-10-2021 13 0 Download
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The progress of medicine, science, technology, education, and culture improves, year by year, quality of life and life expectancy of the populace. The modern human has a chance to further improve the quality and duration of his/her life and the lives of his/her loved ones by bringing their lifestyle in line with their sequenced individual genomes.
23p vibeauty 23-10-2021 19 1 Download
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SQUAMOSA PROMOTER BINDING PROTEIN (SBP)-box genes encode a family of plant-specific transcription factors (TFs) that play important roles in many growth and development processes including phase transition, leaf initiation, shoot and inflorescence branching, fruit development and ripening etc. The SBP-box gene family has been identified and characterized in many species, but has not been well studied in Petunia, an important ornamental genus.
18p vibeauty 23-10-2021 9 0 Download
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The σ54 factor controls unique promoters and interacts with a specialized activator (enhancer binding proteins [EBP]) for transcription initiation. Although σ54 is present in many Clostridiales species that have great importance in human health and biotechnological applications, the cellular processes controlled by σ54 remain unknown.
14p visilicon2711 20-08-2021 13 1 Download
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SQUAMOSA Promoter Binding Protein-Likes (SPLs) proteins are plant-specific transcription factors that play many crucial roles in plant growth and development. However, there is little information about SPL family in the model legume Medicago truncatula.
14p visilicon2711 20-08-2021 9 1 Download
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The plant homeodomain (PHD) finger is a Cys4HisCys3-type zinc finger which promotes proteinprotein interactions and binds to the cis-acting elements in the promoter regions of target genes. In Medicago truncatula, five PHD homologues with full-length sequence were identified. However, the detailed function of PHD genes was not fully addressed.
16p viansan2711 30-07-2021 8 1 Download
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SPL (SQUAMOSA-promoter binding protein-like) proteins form a large family of plant-specific transcription factors that play essential roles in various aspects of plant growth and development. They are potentially important candidates for genetic improvement of agronomic traits.
14p vijeeni2711 24-07-2021 4 0 Download
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Drought is projected to become more frequent and severe in a changing climate, which requires deep sowing of crop seeds to reach soil moisture. Coleoptile length is a key agronomic trait in cereal crops such as barley, as long coleoptiles are linked to drought tolerance and improved seedling establishment under early waterlimited growing conditions.
13p vijichea2711 28-05-2021 14 1 Download
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Members of the plant-specific SPL gene family (squamosa promoter-binding protein -like) contain the SBP conserved domain and are involved in the regulation of plant growth and development, including the development of plant flowers and plant epidermal hair, the plant stress response, and the synthesis of secondary metabolites.
14p vijichea2711 28-05-2021 14 1 Download
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The viral RNA dependent RNA polymerase (L protein) binds to a promoter on each encapsidated segment, and transcribes the mRNA. The virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell. Transcription is terminated by a strong hairpin sequence at the end of each gene, and the transcripts are capped by L protein during synthesis using cap snatching process in the cytoplasm.
10p trinhthamhodang9 16-12-2020 12 1 Download
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Identification of cis- and trans-acting factors regulating gene expression remains an important problem in biology. Bioinformatics analyses of regulatory regions are hampered by several difficulties. One is that binding sites for regulatory proteins are often not significantly over-represented in the set of DNA sequences of interest, because of high levels of false positive predictions, and because of positional restrictions on functional binding sites with regard to the transcription start site.
13p viwyoming2711 16-12-2020 19 0 Download