Protein domains

The exponential growth of bioinformatics in the healthcare domain has revolutionized our understanding of DNA, proteins, and other biomolecular entities. This remarkable progress has generated an overwhelming volume of data, necessitating big data technologies for efficient storage and indexing. While big data technologies like Hadoop offer substantial support for big XML file storage, the challenges of indexing data sizes and XPath query performance persist.

20p dianmotminh02 03-05-2024 2 1   Download

The winged-helix domain within the N-terminus of human MUS81 has been considered as potential target for drug development since the inhibition of this protein might significantly enhance the sensitivity of various cancer cells towards anticancer drugs. Nine cytotoxic triterpenoids previously purified from Helicteres hirsuta and Pterospermum truncatolobatum were selected for the docking experiment.

6p dianmotminh02 03-05-2024 1 1   Download

his study focused on finding alkaloid compounds collected from Chemfaces database that inhibit HER2 enzyme employing computational methods such as molecular docking and ADMET prediction. Out of 118 phytochemicals docked to the ATP binding site of the HER2 kinase domain, 10 alkaloid compounds exhibited higher binding affinity than the reference inhibitor and satisfied the Lipinski’s rule of five. All compounds have good pharmacokinetic properties.

10p dianmotminh02 03-05-2024 4 3   Download

Reconstructing phylogenetic trees from protein sequences normally requires empirical amino acid substitution models to calculate the likelihood of trees or genetic distances between species. The tree of life is classified into three domains of Eukaryotes, Archaea, and Bacteria. The amino acid substitution models have been intensively studied for decades, but few are related to Bacteria. Rooting bacterial trees remains a challenging problem in the phylogenetic analysis due to the long branch separating Bacteria and other domains.

14p dianmotminh02 03-05-2024 4 2   Download

Ebook "Networking of chaperones by co-chaperones" describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets.

152p ladongphongthanh1008 22-04-2024 4 4   Download

Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

222p ladongphongthanh1008 22-04-2024 1 1   Download

Ebook "Endosomes" represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what coordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.

167p ladongphongthanh1008 22-04-2024 2 2   Download

Ebook "Ras superfamily small G proteins: Biology and mechanisms 2 (Transport)" discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases).

299p tracanhphuonghoa1007 22-04-2024 2 2   Download

Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes.

16p vibransone 28-03-2024 3 2   Download

ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane-anchored protein involved in diverse processes including mitochondrial dynamics, mitochondrial DNA organization, and cholesterol metabolism.

21p vibransone 28-03-2024 4 2   Download

Lymphoma represents a heterogeneous group of cancers affecting the lymphatic system, encompassing nonHodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). The majority of NHL cases originate from B cells. HL is characterized by the presence of rare Hodgkin and Reed-Sternberg cells. Within the context of the inflammatory response, two SH2 domain-containing protein tyrosine phosphatases (SHPs), namely SHP-1 and SHP-2, serve as negative regulators.

6p viellison 28-03-2024 2 2   Download

Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.

176p cotieubac1004 15-03-2024 3 0   Download

Classification of rare missense variants remains an ongoing challenge in genomic medicine. Evidence of pathogenicity is often sparse, and decisions about how to weigh different evidence classes may be subjective.

12p vicwell 29-02-2024 10 2   Download

Ebook "The BRICHOS domain: Its proproteins and functions" summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease.

39p manmanthanhla0201 26-02-2024 4 1   Download

Ebook "Kinesin protocols (Methods in molecular biology, Volume 164)" present a wide range of domain organizations with a motor domain located at different positions in the molecule. Their motility properties are also variable in directionality, velocity, and such other characteristics as bundling activity and processivity. Finally, and most important, they practicipate in a multitude of cellular functions.

228p manmanthanhla0201 26-02-2024 3 1   Download

The objective of this study was to analyze the features of FtsZ proteins in the Bacillus and Lactococcus genus groups. By exploring the available genomes, we identified and characterized FtsZ proteins in 19 Bacillus and 22 Lactococcus species.

12p vigojek 02-02-2024 4 0   Download

Ebook "Reviews in fluorescence 2009" topics include: hot electron-induced electrogenerated chemiluminescence; time-correlated, single-photon counting methods in endothelial cell mechanobiology; origin of tryptophan fluorescence; protein folding, unfolding and aggregation processes revealed by rapid sampling of time-domain fluorescence.

395p tachieuhoa 28-01-2024 3 2   Download

Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway. RAF-fusions are the most common genetic alterations identified in JPAs, with the prototypical KIAA1549-BRAF fusion leading to loss of BRAF’s auto-inhibitory domain and subsequent constitutive kinase activation.

13p vileonardodavinci 23-12-2023 4 3   Download

A group of genetically altered cells that have not transformed into a clinical or histologically identifable state of malignancy but contains a higher risk of transforming into one is known as the field of cancerization. Numerous molecules are being investigated for their significance in the development of this phenomenon. One such protein of this family is Kaiso also known as ZBTB33 (Zinc Finger and BTB Domain containing 33).

13p vialfrednobel 23-12-2023 5 3   Download

Galectin-3 (Gal-3), the only chimeric β-galactosides-binding lectin, consists of Gal-3N (N-terminal regulatory peptide) and Gal-3C (C-terminal carbohydrate-recognition domain). Interestingly, Gal-3C could specifically inhibit endogenous full-length Gal-3 to exhibit anti-tumor activity. Here, we aimed to further improve the anti-tumor activity of Gal-3C via developing novel fusion proteins.

16p vischultz 20-10-2023 1 1   Download