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Protein homology
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Part 1 book "Nitrogen fixation - Methods and protocols" includes content: Historic overview of nitrogenase research; mechanism of mo dependent nitrogenase; assembly of nitrogenase mofe protein; genomic analysis of nitrogen fixation; enzymatic systems with homology to nitrogenase; molecular biology and genetic engineering in nitrogen fixation; purification of nitrogenase proteins; assays of nitrogenase reaction products; methods for nitrogenase like dark operative protochlorophyllide oxidoreductase.
155p
dianmotminh04
12-07-2024
0
0
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This paper attempted to clarify the role and mechanism of vacuolar protein sorting-associated protein 72 homolog (VPS72) in the progression of prostate cancer (PCa). In summary our findings suggests that VPS72 could play a crucial role in the malignant progression of PCa, and its expression level can be employed as a possible biomarker of PCa prognosis.
11p
vikoch
27-06-2024
2
1
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Among all types of DNA damage, DNA double-strand breaks (DSBs) are considered the most deleterious form induced by either endogenous factors (oxi-dative damages, mismatches, altered chromatin structures, and missing, or modified nucleotides) or exogenous factors, i.e., ultraviolet (UV) radiation, ionizing radiation (IR), and chemicals or drugs. This study aimed: To evaluate the effect of DNAPKi NU7441 on the HCT116 cell line.
11p
vijaychest
16-05-2024
3
1
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Ebook "Protein dimerization and oligomerization in biology" has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
184p
ladongphongthanh1008
22-04-2024
5
2
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Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.
26p
vibransone
28-03-2024
2
2
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Part 2 book "Handbook of venoms and toxins of reptiles" includes content: Snake venom three finger toxins; sarafotoxins, the snake venom homologs of the endothelins; cysteine rich secretory proteins in reptile venoms; snake venomics and disintegrins - portrait and evolution of a family of snake venom integrin antagonists;... and other contents.
273p
muasambanhan06
03-02-2024
2
1
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Ebook "Plant developmental biology - Biotechnological perspectives (Volume 2)" focuses on development-related areas, including tissue culture (somatic embryogenesis, microspore embryogenesis, somaclonal variation), plant processes (photosynthesis, seed maturation and seed proteins, fatty acids, vitamins, alkaloids, flower pigments and scent), signalling (amino compound-containing lipids, auxins, cytokinins and light), and molecular genetics of developmental regulation (RNA silencing, DNA methylation, epigenetics, activation tagging, homologous recombination and synthetic promoter engineering).
432p
tachieuhoa
28-01-2024
6
2
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Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered insufficient for hepatocarcinogenesis.
16p
vialfrednobel
23-12-2023
6
2
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Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC).BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein.
13p
vischultz
20-10-2023
1
1
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The aquaporin (AQP) family of proteins has been implicated in the proliferation and growth of gliomas. Expression of AQP8 is higher in human glioma tissues than in normal brain tissues and is positively correlated with the pathological grade of glioma, suggesting that this protein is also involved in the proliferation and growth of glioma.
14p
visharma
20-10-2023
7
2
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B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4 domain is required for anti-apoptotic activity.
18p
visharma
20-10-2023
3
2
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This study was performed to identify the non- synonymous polymorphisms in the myosin heavy chain 1 gene (MYH1) association with skeletal muscle development in economically important Jeju Native Pig (JNP) and Berkshire breeds.
16p
vinarcissa
21-03-2023
5
1
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MORE AXILLARY GROWTH 2 (MAX2) is an F-box protein, containing leucine-rich repeats. It is a common regulator in signalling pathways of both karrikin and strigolactone, and has several homologs such as MAX1, MAX3, and MAX4, which play a key role in the biosynthesis of strigolactone. It also interacts with various receptors and repressors of karrikin and strigolactone.
18p
lyhuyenthu
31-01-2023
8
2
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The present study aimed to investigate the association between MKRN3 and LIN28B gene polymorphisms and precocious puberty in Korean boys and girls. This study supports the impact of MKRN3 SNP rs12441827 on precocious puberty in Korean boys. The results add a further aspect to genetic association in precocious puberty along with complex interactions of environmental, nutritional and socioeconomic factors.
7p
vihagrid
30-01-2023
7
3
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The concept of the ‘BRCAness’ phenotype implies the properties that some sporadic breast cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC. Breast tumors with BRCAness have deficiencies in homologous recombination repair (HRR), like BRCA1/2-mutation carriers, and consequently could benefit from poly-(ADP)-ribose poly‑ merase (PARP) inhibitors and DNA-damaging chemotherapy.
13p
visusanwojcicki
28-06-2022
11
2
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The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to BRCA1 that aid their heterodimer interaction to inhibit the progression of different cancers such as breast and ovarian cancers following the BRCA1-dependant pathway.
23p
visusanwojcicki
28-06-2022
9
2
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Nucleolar and spindle-associated protein 1 (NUSAP1) was shown to be involved in cell cycle regulation in cancer. However, its prognostic value and underlying mechanism in ovarian cancer remain unclear.
15p
visusanwojcicki
28-06-2022
10
2
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Optimal functionality of synthetic lung surfactant for treatment of respiratory distress syndrome in preterm infants largely depends on the quality and quantity of the surfactant protein B (SP-B) peptide mimic and the lipid mixture.
12p
vimackenziebezos
29-11-2021
6
1
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For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. The template was removed either by treatment with proteinase K or by alkaline treatment. The measuring signal was generated either by measuring the formation of a product by the target enzyme or by evaluation of the permeability of the redox marker ferricyanide.
9p
tudichquannguyet
29-11-2021
11
2
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Leucine decarboxylase (LDC) is a recently proposed enzyme with no official enzyme commission number yet. It is encoded by the Mus musculus gene Gm853 which is expressed at kidneys, generating isopentylamine, an alkylmonoamine that has not been described to be formed by any metazoan enzyme yet. Although the relevance of LDC in mammalian physiology has not been fully determined, isopentylamine is a potential modulator which may have effects on insulin secretion and healthy gut microbiota formation.
16p
tudichquannguyet
29-11-2021
4
1
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