Protein levels

CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients obtained by TCGA and CGGA databases were used to evaluate the survival rate and prognostic value of CD13 expression level. Protein expression of CD13 was confirmed by immunofluorescence staining of fresh patient tissues.

15p vishanshan 27-06-2024 1 1   Download

CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic biomarkers that predict overall survival in patients undergoing curative hepatic resection for CRC liver metastases.

9p vishanshan 27-06-2024 3 1   Download

PD-L1 showed abnormal mRNA and protein expression in a variety of cancers and predicted prognosis in cancer patients. Furthermore, across a variety of cancer types, the aberrant PD-L1 expression was connected to the MSI, MMR, TMB, drug sensitivity, and tumor immune microenvironment (TIME). Moreover, PD-L1 was significantly correlated with infiltrating levels of immune cells (T cell CD8+, neutrophil, and so on).

19p vishanshan 27-06-2024 1 1   Download

This paper attempted to clarify the role and mechanism of vacuolar protein sorting-associated protein 72 homolog (VPS72) in the progression of prostate cancer (PCa). In summary our findings suggests that VPS72 could play a crucial role in the malignant progression of PCa, and its expression level can be employed as a possible biomarker of PCa prognosis.

11p vikoch 27-06-2024 2 1   Download

Our previous studies have indicated that mRNA and protein levels of PPIH are significantly upregulated in Hepatocellular Carcinoma (LIHC) and could act as predictive biomarkers for patients with LIHC. Nonetheless, the expression and implications of PPIH in the etiology and progression of common solid tumors have yet to be explored, including its potential as a serum tumor marker.

13p vikoch 27-06-2024 1 1   Download

To explore the clinical value of tumor abnormal protein (TAP) in the diagnosis and prognosis evaluation of prostate cancer. Methods This study enrolled a total of 265 patients who underwent prostate biopsy procedures from December 2017. TAP levels were assayed in their blood samples using a validated TAP testing kit.

7p vikoch 27-06-2024 1 1   Download

In this study, all the expressions of Otubain-1, NF-κB2, SHPs and STATs genes, the concentrations of cytokines IL-1β, IL-6 and TNF-α and clinical features in NHL patients were examined. To the end, gene expression levels of 82 NHL patients and 56 healthy individuals were determined by quantitative real time RT-PCR and secretion of cytokines by ELISA.

10p dianmotminh02 03-05-2024 5 1   Download

. In this study, an investigation was conducted to evaluate the expression of genes encoding SOS1, HKT1, HAK10, and NHX1 transporters in the leaf and root tissues of two contrasting rice cultivars, salt tolerant DP and salt sensitive IR28, under salt stress of 150 mM NaCl by RT-qPCR approach. RT-qPCR data revealed that the expression of HKT1, HAK10, SOS1, and NXH1 were upregulated at a higher level in the DP cultivar than in the IR28 cultivar in response to salt stress treatment.

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Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

325p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Systems biology of RNA binding proteins" provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.

474p ladongphongthanh1008 22-04-2024 6 1   Download

Ebook "Carbohydrate-based interactions at the molecular and the cellular level" offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions.

216p tracanhphuonghoa1007 22-04-2024 4 3   Download

The present study was, therefore, conducted to investigate the effect of the addition of different levels of FPI prepared from trimmings of yellowfin tuna on the physicochemical properties and sensory acceptability of biscuits.

7p vijaychest 24-04-2024 3 3   Download

The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear modelbased methods which may fail to account for complex structure and interrelationships within molecular datasets.

15p vibransone 28-03-2024 4 2   Download

The human plasma proteome is important for many biological processes and targets for diagnostics and therapy. It is therefore of great interest to understand the interplay of genetic and environmental factors to determine the specific protein levels in individuals and to gain a deeper insight of the importance of genetic architecture related to the individual variability of plasma levels of proteins during adult life.

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Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based cytometry.

22p vibransone 28-03-2024 6 2   Download

Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into “gene level” effects.

9p vioraclene 31-03-2024 3 2   Download

Clinical genomic testing is dependent on the robust identification and reporting of variant-level information in relation to disease. With the shift to high-throughput sequencing, a major challenge for clinical diagnostics is the cross-identification of variants called on their genomic position to resources that rely on transcript- or protein-based descriptions.

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In ebook "Molecular computing: Origins and promises" an attempt was made to tell about the formation and development of the research on molecular devices of information processing that took place in the atmosphere full of hopes, enthusiasm, successes, and disappointments. It seems to me that it is necessary to write about this now, when there appeared a real possibility to create fundamentally new computing and information-logical devices on the molecular level.

228p tudohanhtau1006 29-03-2024 4 1   Download

Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

248p tudohanhtau1006 29-03-2024 1 1   Download

Ebook "Systems biology and biotechnology of Escherichia coli" covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism.

470p cotieubac1004 15-03-2024 2 0   Download