Protein profile

Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.

11p vishanshan 27-06-2024 3 1   Download

Among gynaecological malignancies, endometrial cancer (EC) is the most prevalent type of uterine cancer affecting women. This study explored the proteomic profiles of plasma samples obtained from EC patients, those with hyperplasia (Hy), and a control group (CO).

17p vikoch 27-06-2024 1 1   Download

Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of Purkinje neurons in the cerebellum.

16p vikoch 27-06-2024 1 1   Download

This study reported that the CHI4A gene was isolated from P. mirifica to validate the CHI4A unigenes obtained from the P. mirifica transcriptomic database (data not shown). This work provides more information about the variation and protein profile of the CHI4A gene for further experiments.

8p dianmotminh02 03-05-2024 7 2   Download

Ebook "Chemical evolution of nitrogen-based compounds in mozzarella cheeses" summarizes how the presence of amines is influenced by different factors such as cheese variety, seasoning and microflora. The authors compare typical profiles of different products, e.g. ripe vs. unripe cheeses, focusing also on the different types of mozzarella cheeses. The Brief also introduces several analytical methods and simulation techniques, which are being used to evaluate the evolutive profiles of different selected molecules, protein aggregation, or proteolysis.

48p tracanhphuonghoa1007 22-04-2024 3 2   Download

Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

14p vibransone 28-03-2024 2 2   Download

The number of druggable tumor-specific molecular aberrations has grown substantially in the past decade, with a significant survival benefit obtained from biomarker matching therapies in several cancer types. Molecular pathology has therefore become fundamental not only to inform on tumor diagnosis and prognosis but also to drive therapeutic decisions in daily practice.

19p vibransone 28-03-2024 2 2   Download

Circular RNAs (circRNAs) are stable, often highly expressed RNA transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been shown to bind RNA-binding proteins (RBPs); however, little is known about the prevalence and distribution of these interactions in different biological contexts.

22p vibransone 28-03-2024 2 2   Download

Ebook "Protein-Protein interactions (Topics in Medicinal chemistry, Volume 8)" surveys the field of inhibitors of the MDM2/p53 interaction, which essentially began with the high-profile disclosure of Nutlins, and quickly and steadily grew through programs at a number of pharmaceutical companies. The MDM2/p53 interaction constitutes a paradigm example of a relatively large, hydrophobic interaction surface for which lead compounds can easily be found.

276p coduathanh1122 27-03-2024 5 1   Download

Ebook "Activity-based proteomics: Methods and protocols" focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

222p lucchinguyen 28-12-2023 18 2   Download

Ebook "Difference gel electrophoresis: Methods and protocols" provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery.

310p lucchinguyen 28-12-2023 6 2   Download

Ebook "Plant chromatin dynamics: Methods and protocols" provides a comprehensive collection of protocols that can be used to study plant chromatin structure and composition. Chapters divided into three sections detail the profiling of chromatin features in relation to epigenetic regulation, investigate the interaction between chromatin modifications and gene regulation, and explore the 3D spatial organization of the chromatin inside the nucleus.

650p lucchinguyen 28-12-2023 6 3   Download

Ebook "Genome instability: Methods and protocols" presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches.

654p lucchinguyen 28-12-2023 6 2   Download

Part 2 book "Farm animal proteomics" includes content: Proteome analysis of muscles longissimus dorsi of Hungarian Merino and Tsigai sheep breeds; muscle proteomics profiles in sheep - the effect of breed and nutritional status, cellular and molecular-large scale features of fetal perirenal and intermuscular adipose tissues in bovine, vegetable based fish feed changes protein expression in muscle of rainbow trout (The proteomic insight of the Italian dry cured ham manufacturing,... and other contents.

86p muasambanhan02 18-12-2023 1 0   Download

Part 2 book "Farm animal proteomics 2013" includes content: Biomarkers of winter disease in gilthead seabream - a proteomics approach, the absorption of colostral proteins in newborn lambs - an iTRAQ proteomics study, plasma proteome profiles predict diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model, changes in protein abundance in the vertebral columnof, atlantic salmon (Salmosalar) fed variable dietary P levels,... and other contents.

129p muasambanhan02 18-12-2023 1 0   Download

Prostate cancer is a major health issue affecting the male population worldwide, and its etiology remains relatively unknown. As presented on the Gene Expression Profiling Interactive Analysis database, acetyl-CoA acetyltransferase 1 (ACAT1) acts as a prostate cancer-promoting factor.

13p vileonardodavinci 23-12-2023 4 2   Download

Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a signifcant break‑ through in treating head and neck squamous cell carcinoma (HNSCC), with long-lasting responses and prolonged survival observed in frst- and second-line therapy. However, this is observed in

9p vileonardodavinci 23-12-2023 6 2   Download

TAP1 is an immunomodulation-related protein that plays different roles in various malignancies. This study investigated the transcriptional expression profile of TAP1 in uveal melanoma (UVM), revealed its potential bio-logical interaction network, and determined its prognostic value.

14p vischultz 20-10-2023 2 1   Download

Prostate cancer is a disease that seriously troubles men. However, there are some inevitable limitations in interventional therapy for prostate cancer patients at present, most of which are caused by low selectivity and high toxic side effects due to unclear drug targets. In this study, we identified the target protein of Curcusone C with antiprostate cancer potential activity and verified its target and mechanism of action.

14p visharma 20-10-2023 5 2   Download

Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival (median survival- 7 months) than patients with LN negative disease (median survival-~23 months) in spite of standard treatment which includes extended surgery followed by chemotherapy, radiotherapy and targeted therapy.

15p visharma 20-10-2023 4 2   Download