Purine metabolism

Part 3 book "Textbook of biochemistry - With clinical correlations" includes content: Lipid metabolism II - pathways of metabolism of special lipids; amino acid and heme metabolism; purine and pyrimidine nucleotide metabolism; metabolic interrelationships; biochemistry of hormones; molecular cell biology; cell cycle, programmed cell death and cancer; digestion and absorption of basic nutritional constituents; vitamins and minerals - requirements and function; macronutrients - metabolic effects and health implications.

501p muasambanhan04 07-01-2024 2 1   Download

Metabolic reprogramming is a hallmark of cancer, alteration of nucleotide metabolism of hepatocellular carcinoma (HCC) is not well-understood. MYBL2 regulates cell cycle progression and hepatocarcinogenesis, its role in metabolic regulation remains elusive.

13p vileonardodavinci 23-12-2023 3 2   Download

Part 3 book "Marks' basic medical biochemistry - A clinical approach" includes content: Protein digestion and amino acid absorption, fate of amino acid nitrogen - urea cycle; synthesis and degradation of amino acids, tetrahydrofolate, vitamin B12, and sadenosylmethionine; purine and pyrimidine metabolism; intertissue relationships in the metabolism of amino acids,....and other contents.

317p oursky07 24-10-2023 5 3   Download

Multiple studies investigated the associations between serum uric acid and coronary heart disease (CHD) risk. However, further investigations still remain to be carried out to determine whether there exists a causal relationship between them.

7p vinarcissa 21-03-2023 4 2   Download

The cytokinin production and transport from root to leaves is hindered under water stress causing leaf senescence due to the synthesis of hydrolytic enzymes. A part of stress effect may be linked to the regulation of osmotic solutes and maintenance of turgidity for stomatal conductance, photosynthesis and protein synthesis accompanied with reduced peroxidation of chloroplast and mitochondrial membranes in pearl millet under kinetin and cycocel treatments.

9p angicungduoc8 07-11-2020 12 2   Download

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research rutin, a bioactive flavonoid was explored to determine the capability of itself and its derivatives to inhibit xanthine oxidase.

13p vijiraiya2711 27-05-2020 13 1   Download

The ureides allantoin and allantoate are major metabolic intermediates of purine catabolism with high nitrogen-to-carbon ratios. Ureides play a key role in nitrogen utilization in ureide-type legumes, but their effects on growth and development in non-legume plants are poorly understood.

16p vishikamaru2711 29-04-2020 10 2   Download

Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).

5p vidublin2711 13-01-2020 12 1   Download

Development of SNPs (Single Nucleotide Polymorphisms) marker is an important step to initiate the molecular breeding and genetic based studies. Identification and validation of polymorphic SNP will be valuable resource for gene tagging through linkage mapping/QTL mapping. In present study, two ecological ecotypes of Arabidopsis thaliana i.e. Col-0 and Don-0 exhibited variation at phenotypic level (leaf, flower, siliques and root related traits) and genotypic level (SNPs). Out of 500 SNPs, total 365 polymorphic SNPs were validated on Sequenome MassARRAY.

16p nguathienthan2 26-12-2019 47 1   Download

Uric acid increased accumulation and/or reduced excretion in human bodies is closely related to pathogenesis of gout and hyperuricemia. It is highly affected by the high intake of food rich in purine. Uric acid is present in both higher plants and microorganisms with species dependent concentration. Uratedegrading enzymes are found both in plants and microorganisms but the mechanisms by which plant degrade uric acid was found to be different among them.

12p trinhthamhodang1 14-11-2019 17 1   Download

Uric acid is a key product of the metabolism of purines, the backbone of Desoxyribonucleic acid (DNA). Being a fundamental component of every living cell, the total Earth’s DNA base pairs is estimated to weigh 50 billion tons [1], which translates into a huge abundance of uric acid in our planet. It would be naive to think of all these virtual heaps of uric acid as useless, inert waste produces. Indeed, they are not. Uric acid in the environment is a rich source of nitrogen (33% of its weight) to plant life, hence its important role in the universal food chain.

4p trinhthamhodang1 14-11-2019 13 0   Download

Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. Mentioning uric acid generates dread because it is the established etiological agent of the severe, acute and chronic inflammatory arthritis, gout and is implicated in the initiation and progress of the metabolic syndrome.

7p trinhthamhodang1 14-11-2019 28 1   Download

(BQ) Continued part 1, part 2 of the document Biochemistry and essentials factors (Second edition) has contents: Water metabolism, mineral metabolism, hemoglobin metabolism, purine and pyrimidine nucleotide metabolism, replication, transcription and translation, genetic engineering, mechanism of hormone action,... and other contents. Invite you to refer.

220p thuongdanguyetan06 06-06-2019 25 1   Download

(BQ) Continued part 1, part 2 of the document BRS biochemistry molecular biology and genetics presents the following contents: Lipid and ethanol metabolism; nitrogen metabolism–amino acids, purines, pyrimidines and products derived from amino acids; molecular endocrinology and an overview of tissue metabolism, human genetics—an introduction.

220p thangnamvoiva4 01-07-2016 75 12   Download

Virtually all cells are capable of synthesizing purine and pyrimidine nucleotides. These compounds then serve as essential intermediates in metabolism and as the building blocks for DNA and RNA synthesis. In this chapter you will learn: How do cells synthesize purines and pyrimidines?

53p tangtuy15 30-06-2016 42 4   Download

(BQ) Continued part 1, part 2 of the document Elsevier's integrated review biochemistry presents the following contents: Metabolism of steroids and other lipids, amino acid and heme metabolism; integration of carbohydrate, fat and amino acid metabolism; purine, pyrimidine, and single carbon metabolism; organization, synthesis and repair of DNA,...

148p thangnamvoiva3 28-06-2016 49 2   Download

(BQ) Continued part 1, part 2 of the document Elsevier’s integrated review biochemistry presents the following contents: Fatty acid and triglyceride metabolism, metabolism of steroids and other lipids, amino acid and heme metabolism; integration of carbohydrate, fat, and amino acid metabolism; purine, pyrimidine, and single carbon metabolism,...Invite you to consult.

156p thangnamvoiva2 23-06-2016 28 3   Download

(BQ) Continued part 1, part 2 of the document Textbook of biochemistry with clinical correlations presents the following contents: Amino acid metabolism, purine and pyrimidine nucleotide metabolism, metabolic interrelationships, structure and conformation, repair, synthesis and recombination...

735p thangnamvoiva2 23-06-2016 78 7   Download

Gút là một bệnh do tăng acid uric -máu, trong dịch bao khớp có nhiều tinh thể urat là sản phẩm chuyển hóa cuối cùng của purin. Bệnh có thể nguyên phát do rối loạn chuyển hóa acid uric di truyền, hoặc thứ phát do bệnh thận, do dùng các thuốc phong tỏa thải trừ urat hoặc do sản xuất quá nhiều urat (metabolic overproduction).

8p truongthiuyen7 21-06-2011 68 2   Download

Gút là một bệnh do tăng acid uric -máu, trong dịch bao khớp có nhiều tinh thể urat là sản phẩm chuyển hóa cuối cùng của purin. Bệnh có thể nguyên phát do rối loạn chuyển hóa acid uric di truyền, hoặc thứ phát do bệnh thận, do dùng các thuốc phong tỏa thải trừ urat hoặc do sản xuất quá nhiều urat (metabolic overproduction). Acid uric-máu bình thường là 2 -5mg/100ml, trong bệnh gút có thể tăng tới 8,8mg/100ml. Điều trị gút nhằm giải quyết cơn cấp tính và ngăn ngừa sự tái nhiễm, dựa trên sinh bệnh học...

5p super_doctor 25-10-2010 92 13   Download