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Rat plasma
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The status of chromium as an essential nutrient is an ongoing debate despite its widespread use as supplement. Chromium supplement has been reported to improve glucose tolerance, insulin action and promote weight loss. This study examined the effect of given high concentrations of glucose D to chromium picolinate pretreated rats.
4p
viisac
23-09-2023
6
1
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Ischemia-reperfusion (I/R) is a critical pathophysiological basis of cognitive dysfunction caused by ischemia stroke. Heme-oxygenase-1 (HO-1) is the rate-limiting enzyme for the elimination of excessive free heme by combining with hemopexin (HPX), a plasma protein that contributes to eliminating excessive free heme during ischemia stroke.
9p
vampires36
30-12-2021
7
0
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Ischemia-reperfusion (I/R) is a critical pathophysiological change of ischemic stroke. Heme-oxygenase-1 (HO-1) is a rate-limiting enzyme of eliminating excessive free heme by combining with hemopexin (HPX), a plasma protein contributing to alleviating infarct size due to ischemia stroke. This study was to investigate whether HPX could improve angiogenesis after cerebral ischemia-reperfusion via up-regulating HO-1.
7p
vampires36
30-12-2021
16
0
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High-intensity ultrasound has been used to induce acoustic cavitation in the skin and subsequently enhances skin permeability to deliver hydrophobic topical medications including lidocaine. In contrast, instead of changing skin permeability, pulsed application of low-intensity focused ultrasound (FUS) has shown to noninvasively and temporarily disrupt drug-plasma protein binding, thus has potential to enhance the anesthetic effects of hydrophilic lidocaine hydrochloride through unbinding it from serum/interstitial α1-acid glycoprotein (AAG).
11p
vidietmarhopp
28-12-2021
11
0
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Huyết tương giàu tiểu cầu (Platelet rich plasma - PRP) là huyết tương tự thân có hàm lượng tiểu cầu cao hơn rất nhiều so với lượng tiểu cầu trung bình trong máu ngoại vi. PRP chứa một lượng lớn các nhân tố tăng trưởng và cytokine như: PDGF, EGF, VEGF, TGF-β,... tham gia vào quá trình tái tạo và chữa lành vết thương.
11p
vijihyo2711
25-09-2021
27
1
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Evaluation of in vivo antidiabetic activity of umbelliferone in streptozotocin induced diabetic rats
The first line of treatment in Diabetes mellitus includes the use of oral hypoglycemic agents which are associated with several side effects. Herbal agents are known for their effectiveness due to their fewer side effects and relatively low cost. Umbelliferone, a coumarin has been reported to reduce or decrease blood glucose, elevated plasma insulin, protein profile, and cause hypolipidemic effect. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg b.wt., umbelliferone at 40 mg/kg b.wt. and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt.
12p
caygaocaolon11
21-04-2021
13
0
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This study aims to find out whether extracellular miRNAs is implicated in recurrent childhood wheezing with asthmatic risk. Methods: One hundred and forty children of Chinese Han population were recruited for this study. Plasma and intracellular miRNAs from children with recurrent wheezing and rats with antigen induced pulmonary inflammation (AIPI) were detected by using reverse transcription-quantitative PCR.
11p
vimaine2711
26-03-2021
13
1
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Exposure to environmental tobacco smoke (ETS) leads to higher rates of pulmonary diseases and infections in children. To study the biochemical changes that may precede lung diseases, metabolomic effects on fetal and maternal lungs and plasma from rats exposed to ETS were compared to filtered air control animals.
15p
viwyoming2711
16-12-2020
11
1
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The pharmacokinetics and anti-inflammatory activity of andrographolide (50 mg/kg) were studied following intramuscular administration in rats. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC).
6p
angicungduoc8
07-11-2020
7
1
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5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model.
7p
vialabama2711
21-09-2020
15
1
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Pharmacokinetic activity of Quercetin (100 mg/kg) was studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC) following intramuscular administration of Quercetin (100 mg/kg) in rats.
5p
nguathienthan5
04-06-2020
13
1
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The pharmacokinetics, antibacterial and anti-inflammatory activities of Chrysin (100 mg/kg) were studied following intramuscular administration in rats. Drug concentration in rat plasma was determined using High Performance Liquid Chromatography (HPLC).
10p
trinhthamhodang1213
30-05-2020
13
1
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The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its main metabolite valdecoxib in rat plasma.
10p
viorochimaru2711
30-05-2020
10
1
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Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with refractory gout.
7p
vijiraiya2711
27-05-2020
9
0
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To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs).
9p
vijiraiya2711
27-05-2020
18
2
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In this work, we aim to develop and validate a fast, simple, and sensitive method for the quantitative determination of flibanserin and the exploration of its pharmacokinetics.
8p
vijiraiya2711
27-05-2020
13
1
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A sensitive, specific, reproducible and optimized high performance liquid chromatography with fluorescence detection (HPLC-FLD) method for the determination of bergapten in rat plasma was established and applied to the pharmacokinetic and bioavailability study in rat after oral and intravenous administration of bergapten.
8p
vijiraiya2711
27-05-2020
10
0
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Vandetanib (VNT) is a new oral tyrosine kinase inhibitor that acts mainly by inhibiting vascular endothelial growth factor receptor (VEGFR). Fast, specific, sensitive and validated LC–MS/MS was established for the determination of VNT in two various matrices including rat liver microsome (RLMs) and human plasma.
8p
vijiraiya2711
27-05-2020
15
1
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Muscle injuries present frequently in sports medicine. Healing with conventional therapy is often inadequate, leading to incomplete functional recovery due to fibrosis. Generating substantial interest in the potential for emerging technologies such as platelet-rich plasma (PRP) to enhance soft-tissue healing and decrease time of recovery became mandatory. The aim of this work was to evaluate the role of PRP in promoting healing of experimentally induced skeletal muscle injury in adult male albino rat model. 48 adult male albino rats were used and were divided into three groups.
9p
trinhthamhodang5
16-05-2020
8
1
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This work aimed at improving the solubility of curcumin by the preparation of spray-dried ternary solid dispersions containing Gelucire®50/13-Aerosil® and quantifying the resulting in vivo oral bioavailability and anti-inflammatory activity. The solid dispersion containing 40% of curcumin was characterised by calorimetry, infrared spectroscopy and X-ray powder diffraction. The solubility and dissolution rate of curcumin in aqueous HCl or phosphate buffer improved up to 3600- and 7.3-fold, respectively.
10p
caothientrangnguyen
09-05-2020
14
2
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