Recombination and pathogenesis

Bacterial lipoproteins play crucial roles in host–pathogen interactions and pathogenesis and are important targets for the immune system. A promi-nent example is the outer surface protein A (OspA) ofBorrelia burgdorferi, which has been efficiently used as a vaccine for the prevention of Lyme dis-ease.

10p media19 04-03-2013 37 3   Download

Aggregation of the normal cellular prion protein, PrP, is important in the pathogenesis of prion disease. PrP binds glycosaminoglycan (GAG) and divalent cations, such as Cu 2+ and Zn 2+ . Here, we report our findings that GAG and Cu 2+ promote the aggregation of recombinant human PrP (rPrP).

12p vinaphone15 28-02-2013 42 4   Download