
Báo cáo khoa học: Ligand binding promotes prion protein aggregation – role of the octapeptide repeats
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Aggregation of the normal cellular prion protein, PrP, is important in the pathogenesis of prion disease. PrP binds glycosaminoglycan (GAG) and divalent cations, such as Cu 2+ and Zn 2+ . Here, we report our findings that GAG and Cu 2+ promote the aggregation of recombinant human PrP (rPrP).
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