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Regulatory landscape
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The study culminates in recommendations for continued exploration of emerging trends, regulatory considerations, and the development of robust tokenomics in the evolving DeFi landscape, emphasizing responsible data usage and adherence to industry standards. This research provides a nuanced perspective on the transformative potential of blockchain in financial ecosystems, catering to academic and industry audiences alike.
15p
dathienlang1012
03-05-2024
2
0
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Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.
16p
vioraclene
31-03-2024
2
2
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Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity— however, most predicted enhancer regions remain to be functionally tested.
25p
vibransone
28-03-2024
5
2
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Alternative splicing complexity plays a vital role in carcinogenesis and cancer progression. Improved understanding of novel splicing events and the underlying regulatory mechanisms may contribute new insights into developing new therapeutic strategies for colorectal cancer (CRC).
24p
vicwell
29-02-2024
2
2
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Ebook "Evolutionary developmental biology of invertebrates - Volume 6: Deuterostomia" is a must-have for any scientist, teacher or student interested in developmental and evolutionary biology as well as in general invertebrate zoology. This chapter is dedicated to the Deuterostomia, comprising the Echinodermata and Hemichordata (usually grouped together as the Ambulacraria) as well as the Cephalochordata and the Tunicata.
220p
manmanthanhla0201
26-02-2024
4
1
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Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Forty-one fresh lung adenocarcinoma (ADC) tissues were analyzed using flow cytometry for comprehensive immunoprotein. Formalin-fixed tissues were immunostained for hexokinase-2 (HK2) to assess cancer cell glycolysis.
11p
vileonardodavinci
23-12-2023
6
3
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Ebook "The new global regulatory landscape: Impacts on finance and investment" provides a benchmark tool for financial intermediaries and Institutional Investors. Covering 24 international regulations across the UK, Europe, Asia/Pacific and the USA, the authors provide practical compliance tips for financial intermediaries and guidance on best practice for investors. The book highlights eight areas of critical overlap where regulatory requirements conflict and give rise to potential risk and liability.
250p
loivantrinh
29-10-2023
6
4
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The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells
Transcription factors (TFs) control gene expression by direct binding to regulatory regions of target genes but also by impacting chromatin landscapes and modulating DNA accessibility for other TFs. In recent years several TFs have been defined that control cell fate decisions and effector functions in the immune system.
20p
vihagrid
30-01-2023
6
3
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Our browser provides multiple methods linking distal cis-regulatory elements with their potential target genes. Users can seamlessly integrate thousands of other omics data to gain a comprehensive view of both regulatory landscape and 3D genome structure.
12p
vigalileogalilei
27-02-2022
12
1
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Chromatin loops form a basic unit of interphase nuclear organization, with chromatin loop anchor points providing contacts between regulatory regions and promoters. However, the mutational landscape at these anchor points remains under-studied. Here, we describe the unusual patterns of somatic mutations and germline variation associated with loop anchor points and explore the underlying features influencing these patterns.
14p
vigalileogalilei
27-02-2022
15
1
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Recent innovations in single-cell Assay for Transposase Accessible Chromatin using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands of individual cells. scATAC-seq data analysis presents unique methodological challenges.
25p
vielonmusk
30-01-2022
9
0
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The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by regulatory elements located in the centromeric TAD (C-DOM) through long-range contacts.
15p
vialfrednobel
29-01-2022
13
0
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Whole-genome bisulfite sequencing (WGBS) is the gold standard for studying landscape DNA methylation. Current computational methods for WGBS are mainly designed for gene regulatory regions with multiple under-methylated CpGs (UMCs), such as promoters and enhancers.
10p
vialfrednobel
29-01-2022
10
0
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One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain.
13p
vialfrednobel
29-01-2022
7
1
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Open chromatin regions are correlated with active regulatory elements in development and are dysregulated in diseases. The BAF (SWI/SNF) complex is essential for development, and has been demonstrated to remodel reconstituted chromatin in vitro and to control the accessibility of a few individual regions in vivo.
17p
viaristotle
29-01-2022
14
0
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Linker histone H1 is a core chromatin component that binds to nucleosome core particles and the linker DNA between nucleosomes. It has been implicated in chromatin compaction and gene regulation and is anticipated to play a role in higher-order genome structure.
15p
viaristotle
29-01-2022
9
0
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: Spatiotemporal changes in the chromatin accessibility landscape are essential to cell differentiation, development, health, and disease. The quest of identifying regulatory elements in open chromatin regions across different tissues and developmental stages is led by large international collaborative efforts mostly focusing on model organisms, such as ENCODE.
20p
viarchimedes
26-01-2022
12
0
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Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron retention that modulate gene expression.
26p
viarchimedes
26-01-2022
10
0
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The functional genome of agronomically important plant species remains largely unexplored, yet presents a virtually untapped resource for targeted crop improvement. Functional elements of regulatory DNA revealed through profiles of chromatin accessibility can be harnessed for fine-tuning gene expression to optimal phenotypes in specific environments.
33p
viarchimedes
26-01-2022
10
0
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Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) is the state-of-the-art technology for analyzing genome-wide regulatory landscapes in single cells. Single-cell ATAC-seq data are sparse and noisy, and analyzing such data is challenging.
36p
viarchimedes
26-01-2022
8
0
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