Relative efficacy
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Novel antibody-drug conjugates (ADCs) drugs present a promising anti-cancer treatment, although survival benefits for HER2-positive advanced breast cancer (BC) remain controversial. The aim of this meta-analysis was to evaluate the comparative effect of ADCs and other anti-HER2 therapy on progression-free survival (PFS) and overall survival (OS) for treatment of HER2-positive locally advanced or metastatic BC.
10p vikoch 27-06-2024 1 1 Download
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Nasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes. High-dose radiotherapy is a key treatment for patients with NACC. This study reported the long-term efficacy and safety of particle beam radiation therapy (PBRT) for NACC.
7p vikoch 27-06-2024 2 1 Download
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The occurrence of surgical site infection (SSI) after pancreaticoduodenectomy (PD) is still relatively high. The aim of this retrospective study is to evaluate the efficacy of piperacillin-tazobactam as perioperative prophylactic antibiotic on organ/space SSI for patients underwent PD.
10p vikoch 27-06-2024 1 1 Download
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S-1 adjuvant chemotherapy is the standard treatment in Asia for resectable pancreatic ductal adenocarcinoma. The relative dose intensity of adjuvant chemotherapy influences survival in pancreatic cancer but does not precisely reflect treatment schedule modifications. We investigated the effects of total dose intensity of S-1 adjuvant chemotherapy on the survival of patients with pancreatic cancer and the permissible dose reduction.
9p vialfrednobel 23-12-2023 7 3 Download
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Ataluren is a relatively new treatment for male patients with Duchenne muscular dystrophy (DMD) due to a premature stop codon. Long-term longitudinal data as well as efficacy data on non-ambulant patients are still lacking.
10p vimackenziebezos 30-11-2021 6 1 Download
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Trichophyton mentagrophytes is an important zoonotic dermatophytic (ringworm) pathogen; causing severe skin infection in humans and other animals worldwide. Fortunately, commonly used fungal skin disease prevention and treatment measures are relatively simple. However, T. mentagrophytes is primarily studied at the epidemiology and drug efficacy research levels, yet current study has been unable to meet the needs of clinical medicine.
12p vilarryellison 29-10-2021 7 0 Download
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The incidence and severity of Alternaria blight in rapeseed-mustard fields is greatly influenced by temperature, relative humidity, soil condition at the time of planting, splashing rain, wind velocity, leaf wetness and inoculum density available in the soil (Meena et al., 2004).
6p trinhthamhodang11 27-04-2021 11 1 Download
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Osteosarcoma is a relatively rare malignant tumor with a high incidence in young people. The development of tyrosine kinase inhibitors has brought the treatment of osteosarcoma into a new stage.
11p vianrose2711 27-04-2021 11 1 Download
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Pelubiprofen is a prodrug of 2-arylpropionic acid with relatively selective effects on cyclooxygenase-2 activity. The aim of this study was to compare the efficacy and safety profiles of pelubiprofen with those of celecoxib in patients with rheumatoid arthritis.
9p viannito2711 20-04-2021 10 1 Download
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The objective of this study was to evaluate the comparative efficacy of indacaterol 75 μg once daily (OD), tiotropium 18 μg OD, salmeterol 50 μg twice daily (BID), formoterol 12 μg BID, and placebo for the treatment of chronic obstructive pulmonary disease (COPD) based on individual patient data (IPD) from randomized controlled trials (RCTs) from the indacaterol trial program and aggregate data (AD) identified from a systematic review of RCTs.
15p vianthony2711 16-04-2021 5 1 Download
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Forced expiratory volume in 1 second (FEV1) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV1 is relatively insensitive to changes in the small airways of patients with milder lung disease. This pilot study aimed to explore the lung clearance index (LCI) as a marker for use in efficacy trials with inhaled antibiotics in CF.
8p vimichigan2711 26-03-2021 6 1 Download
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Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, length of hospitalization and ICU stay in AIDS/hematological malignancy patients with relatively less severe ARF, compared to invasive mechanical ventilation (IMV).
10p vimaine2711 26-03-2021 14 2 Download
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This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS). Both doses of etoricoxib were non-inferior to naproxen. All treatments were well tolerated. Etoricoxib 60 and 90 mg effectively control pain in patients with AS, with 60 mg once daily as the lowest effective dose for most patients.
12p vitennessee2711 02-02-2021 8 2 Download
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Low back pain is common and associated with a considerable burden to patients and society. There is uncertainty regarding the relative benefit of paracetamol and diclofenac and regarding the additional effect of pain medication compared with advice only in patients with acute low back pain.
9p vitennessee2711 02-02-2021 11 3 Download
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Geriatric hip fracture patients are particularly susceptible to blood loss and venous thromboembolism (VTE) during hemiarthroplasty, yet relatively few studies have examined the safety and efficacy of tranexamic acid (TXA) in these patients.
9p vivermont2711 28-01-2021 15 2 Download
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The experiment was conducted to study of biology of H. armigera in relation to abiotic factors (temperature, relative humidity, rainfall etc.), to evaluate the efficacy of some botanicals and organic compounds against H. armigeraand workout the economics of different treatments with Incremental Cost Benefit Ratio (ICBR), H. armigera on field pea in Rabi 2018-19.
5p trinhthamhodang9 16-12-2020 13 2 Download
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Climate change is a natural and continuous process. But recent relatively rapid change in climate occurs due to anthropogenic activities which makes alarming attention because it contributes largely to global warming by affecting the greenhouse gases (GHGs) and aerosols. GHGs mainly CO2, methane, nitrous oxide CFC11, CFC12, HCFC22and HFC23 with different global warming potential accumulate in atmosphere and increase in concentration over time creating the so called “greenhouse effect”.
8p caygaocaolon8 07-11-2020 23 2 Download
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A field experiment was conducted at Main Vegetable Research Station,Anand Agricultural University, Anand (Gujarat) during kharif-rabi seasons of the year 2014-15 and 2015-16 to assess the efficacy of different nine acaricides against brinjal miteviz., fenazaquin 0.01%, diafenthiuron 0.05%, spiromesifen 0.02%, dicofol 0.05%, ethion 0.05%, chlorfenapyr 0.01%, propargite0.06%, fenpyroximate 0.005% as well as wettable sulphur 0.16% compared with control.
11p nguaconbaynhay8 13-10-2020 12 2 Download
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Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. In the present investigation hypoglycemic efficacy of methanol extract of Catharanthus roseus (Nayantara) of Apocyanaceae and Opuntia ficusindica of Cactaceae was tested on STZ induced mice diabetic models.
17p chauchaungayxua8 03-10-2020 11 1 Download
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The Michigan Prevention Research Center, the University of Michigan Schools of Nursing, Public Health, and Medicine, and the Michigan Department of Community Health propose a multidisciplinary academicclinical practice three-year project to increase breast cancer screening among young breast cancer survivors and their cancer-free female relatives at greatest risk for breast cancer.
9p vijisoo2711 29-09-2020 10 0 Download