RNA methylation

The research project deals with two different types of data for two separate analysis. The first analysis deals with normalised RNA-seq breast cancer data where machine learning techniques are used to classify and identify the biomarker of cancer. Second analysis deals with raw DNA methylated leukemia samples to determine the mutations.

102p runthenight04 02-02-2023 6 3   Download

Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, suggesting germline transmission. We have previously shown that prenatal overexposure to the synthetic glucocorticoid dexamethasone (Dex) in rats reduces birth weight in the first generation (F1), a phenotype which is transmitted to a second generation (F2), particularly through the male line.

15p vimichaelfaraday 25-03-2022 15 1   Download

N6 -methyladenosine (m6 A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved in the regulation of memory formation and mammalian cortical neurogenesis.

18p vimichaelfaraday 25-03-2022 13 1   Download

Bioremediation presents a potentially low cost and environmentally agreeable alternative to current physico-chemical remediation strategies. However, heavy metals such as mercury cannot be converted into non-toxic forms by naturally occurring bacteria. Annual global emissions estimates for mercury released into the environment are in the thousands of tons per year [1,2] while the remediation cost is in the thousands of dollars per pound. Finding new bioremediation technologies is an urgent need.

8p zingzing09 24-04-2013 44 3   Download

Special oligonucleotides for targeted gene correction have attracted increasing attention recently, one of which is the chimericRNAÆDNAoligonucleotide (RDO) system. RDOs for targeted gene correction were first designed in 1996, and are typically 68 nucleotides in length including continuous RNA andDNA sequences (RNA is 2¢-O-methyl-modified).

6p tumor12 22-04-2013 33 2   Download

The human 2¢)5¢ oligoadenylate synthetases (OAS) form a conserved family of interferon-induced proteins consisting of four genes:OAS1, OAS2, OAS3and the 2¢)5¢ oligo-adenylate synthetase-like gene (OASL). When activated by double-strandedRNA,OAS1–3polymerizeATP into2¢)5¢-linkedoligoadenylates; 2¢)5¢-linkedoligoadenylates, in turn, activate a latent endoribonuclease that degrades viral and cellular RNAs. In contrast, while the p59 OASLprotein is highlyhomologous to theOAS family (45%identity), its 350 amino acid N-terminal domain lacks 2¢)5¢ oligoadenylate synthetase activity. ...

9p dell39 03-04-2013 43 5   Download

Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are several pathways, including histone tail mod-ifications, histone variant incorporation, nucleosome remodelling, DNA methylation and noncoding RNAs that together all contribute to the dynamic ‘make-up’ of chromatin under distinct developmental options.

15p inspiron33 25-03-2013 39 4   Download

MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene expression post-transcriptionally. Recent studies have demon-strated that epigenetic mechanisms, including DNA methylation and his-tone modification, not only regulate the expression of protein-encoding genes, but also miRNAs, such as let-7a, miR-9, miR-34a, miR-124, miR-137, miR-148 and miR-203.

12p cosis54 05-01-2013 44 5   Download

Tên chung quốc tế: Procarbazine. Mã ATC: L01X B01. Loại thuốc: Thuốc chống ung thư. Dạng thuốc và hàm lượng Viên nang: 50 mg. Dược lý và cơ chế tác dụng Procarbazin là dẫn chất hydrazin có tác dụng chống ung thư. Cơ chế tác dụng độc tế bào của procarbazin chưa biết được đầy đủ. Có bằng chứng cho thấy thuốc này có tác dụng bằng cách ức chế tổng hợp protein, RNA và DNA. Procarbazin có thể ức chế sự chuyển nhóm methyl của methionin vào t - RNA (RNA vận chuyển). Thiếu vắng t - RNA...

8p daudam 16-05-2011 82 7   Download

Uracil là một trong bốn loại nucleobase trong RNA, thay vì thymine như trong DNA. Tương tự thymine, uracil có thể tạo thành một cặp base vớiadenine qua hai liên kết hiđrô, tuy nhiên nó kém thua thymine một nhóm methyl. Uracil, so với thymine, dễ bị thoái hóa hơn thành cytosine. Uracil hiếm khi hiện diện trong DNA.

3p heoxinhkute5 16-11-2010 102 7   Download