RNA Processing II

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Lecture Molecular biology (Fifth Edition): Chapter 15 - Robert F. Weaver

Chapter 15 - RNA Processing II: Capping and Polyadenylation. Besides splicing, eukaryotic cells perform several other kinds of processing on their RNAs. Messenger RNAs are subject to two kinds of processing, known as capping and polyadenylation. In capping, a special blocking nucleotide (a cap) is added to the 59-end of a pre-mRNA. In polyadenylation, a string of AMPs (poly[A]) is added to the 39-end of the pre-mRNA. These steps are essential for the proper function of mRNAs and will be topics in this chapter.

31p tangtuy05 30-03-2016 54 3 Download

Báo cáo khoa học: Functional interaction between RNA helicase II⁄Gua and ribosomal protein L4

RNA helicase II⁄Guais a multifunctional nucleolar protein involved in ribosomal RNA processing inXenopus laevisoocytes and mammalian cells. Downregulation of Guausing small interfering RNA (siRNA) in HeLa cells resulted in 80% inhibition of both 18S and 28S rRNA production. The mechanisms underlying this effect remain unclear. Here we show that in mammalian cells, Guaphysically interacts with ribosomal protein L4 (RPL4), a component of 60S ribosome large subunit.

15p fptmusic 11-04-2013 36 2 Download

Báo cáo khóa học: Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II plays critical roles in the initiation, elongation and processing of primary transcripts. These activities are at least partially regulated by the phosphory-lation of the CTDby three cyclin-dependent protein kinases (CDKs), namely CDK7, CDK8 and CDK9. In this study, we systematically compared the phosphorylation of differ-ent recombinant CTD substrates by recombinant CDK7/ CycH/MAT1, CDK8/CycCandCDK9/CycT1 kinases.We showed that CDK7, CDK8 and CDK9 produce different patterns of phosphorylation of the CTD. ...

11p dell39 03-04-2013 43 3 Download
Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron

Group II introns are both catalytic RNAs and mobile retroelements that move through a process catalyzed by a RNP complex consisting of an intron-encoded protein and the spliced intron lariat RNA. Group II intron-encoded proteins are multifunctional and contain an N-terminal reverse transcriptase domain, followed by a putative RNA-binding domain (domain X) associated with RNA splicing or maturase activity and a C-terminal DNA binding⁄DNA endonuclease region.

11p mobifone23 18-01-2013 35 4 Download