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Báo cáo khoa học: Functional interaction between RNA helicase II⁄Gua and ribosomal protein L4
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RNA helicase II⁄Guais a multifunctional nucleolar protein involved in ribosomal RNA processing inXenopus laevisoocytes and mammalian cells. Downregulation of Guausing small interfering RNA (siRNA) in HeLa cells resulted in 80% inhibition of both 18S and 28S rRNA production. The mechanisms underlying this effect remain unclear. Here we show that in mammalian cells, Guaphysically interacts with ribosomal protein L4 (RPL4), a component of 60S ribosome large subunit.
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