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Schistosomiasis

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  • Artemether (ART), the methylated derivative of artemisinin, is an efficacious antimalarial drug that also displays antischistosomal properties. This study was designed to evaluate the immunomodulatory action of a single intramuscular dose (50 mg/kg body weight) of ART in comparison with PZQ treatment (42 days PI). ART administration was 7, 14, 21 and 45 days PI. ART effect was studied parasitologically, histopathologically and immunologically. It was found that maximum effect was reached when ART treatment interfered with 14 or 21 days old schistosomula.

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  • Role of different mediators was described in the development of the granulomatous response and fibrosis observed in intestinal schistosomiasis. However, both Toll-like receptor 2 (TLR2) and nuclear factor kappa B (NF-jB) have not yet been investigated in intestinal schistosomiasis. This study aimed to characterize the role of TLR2 and NF-jB in the pathogenesis of intestinal schistosomiasis. Experimental animals were divided into two groups; group I: non-infected control group and group II: mice infected subcutaneously with S. mansoni cercariae.

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  • Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to 90% was achieved, providing a sound proof that vaccination against this infection is feasible.

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  • Schistosomiasis is a parasitic disease caused by blood flukes (Trematodes) of the genus Schistosoma (S.). It is well documented that schistosomiasis haematobium was endemic in Ancient Egypt. Infection was diagnosed in mummies 3000, 4000 and 5000 years old. Scott was the first to describe the pattern of schistosomiasis infection in Egypt. Schistosomiasis haematobium was highly prevalent (60%) both in the Nile Delta and Nile Valley South of Cairo in districts of perennial irrigation while it was low (6%) in districts of basin irrigation.

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  • Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

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  • The clinical manifestations of schistosomiasis pass by acute, sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate, TH1 and TH2 adaptive stages, with an ultimate establishment of concomitant immunity. Some patients may also develop late complications, or suffer the sequelae of co-infection with other parasites, bacteria or viruses. Acute manifestations are species-independent; occur during the early stages of invasion and migration, where infection-naivety and the host’s racial and genetic setting play a major role.

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  • Schistosomiasis is not known to be associated with any malignant disease other than bladder cancer. Bladder cancer is still the most common malignant tumor among males in Egypt and some African and Middle East countries. However, the frequency rate of bladder cancer has declined significantly during the last 25 years. This drop is mainly related to the control of Schistosomiasis. Many studies have elucidated the pathogenic events of Schistosomal-related bladder cancer with a suggested theory of pathogenesis.

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  • In this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, usually due to Schistosoma haematobium infection, are attributed to the formation of granulomata along the entire urinary tract. As they heal with excessive fibrosis, they may lead to strictures, calcifications and urodynamic abnormalities.

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  • Chromogenic medium is culture media for simple and fast detection of bacteria using chromogenic substrates, resulting in the different coloration of certain bacteria colonies. Have several advantages over traditional media, such as cysteine-lactose-electrolyte deficient (CLED) medium, allow for easier recognition of mixed growth, save time, reduce workload and provides higher detection rates. To compare between chromogenic colour agar and biochemical tests in identification of organisms causing bacteriuria that associated with urinary Schistosomiasis.

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  • Schistosomiasis is a major disease of the developing world. Despite integrated control measures, schistosomiasis continues to spread to new regions. So, there is a pressing need to identify new antigens and to explore new adjuvants to improve vaccine efficacy. The aim of the present study was to evaluate the efficacy of an adjuvant dendritic cell (DC) combined with S. mansoni SEA and SWAP antigens as vaccination in mice experimentally infected with S. mansoni. The study was carried out on 70 laboratory bred Swiss albino male mice.

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  • Reports on schistosomiasis epidemiology and clinical features in Africa and Brazil, and development of novel drugs that affect the worm tegument, and vaccine based on excretory-secretory products and Type 2 cytokines.

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Colorectal carcinoma associated with schistosomiasis: a possible causal relationship

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  • as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it

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  • Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. Mentioning uric acid generates dread because it is the established etiological agent of the severe, acute and chronic inflammatory arthritis, gout and is implicated in the initiation and progress of the metabolic syndrome.

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  • Schistosomiasis is a debilitating disease affecting approximately 600 million people in 74 developing countries, with 800 million, mostly children at risk. To circumvent the threat of having praziquantel (PZQ) as the only drug used for treatment, several PZQ derivatives were synthesized, and drugs destined for other parasites were used with success.

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  • Schistosomiasis associated pulmonary arterial hypertension (Sch-PAH) might represent the most prevalent form of PAH worldwide. In Sch-PAH, the presence of aneurismal dilation of the pulmonary artery has been described, although it is still a matter of debate whether on average the pulmonary artery is more enlarged in Sc-PAH than IPAH.

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  • Schistosomiasis is caused by digenetic blood trematodes. The three main species infecting humans are Schistosoma haematobium, S. japonicum, and S. mansoni. Two other species, more localized geographically, are S. mekongi and S. intercalatum. In addition, other species of schistosomes, which parasitize birds and mammals, can cause cercarial dermatitis in humans.

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  • Some years later Stamey modified the sextant technique and took sextant biopsies that were lateral to the mid-sagittal plane in the peripheral zone where most prostate cancers are typically located (Stamey, 1995). Other investigators went on to study alternatives to the traditional sextant biopsy, namely the optimum number of core biopsies for diagnosis as well as sampling of the transition zone in an effort to improve the negative predictive value of prostate biopsy. Intuitively researchers began sampling more prostatic tissue however the procedure was not without pain.

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  • (BQ) Continued part 1, part 2 of the document Infectious diseases - Radiology has contents: Neonatal tetanus, other infectious diarrhea, pulmonary tuberculosis, typhoid and paratyphoid fever, schistosomiasis, radiology of parasitic infections,... and other contents. Invite you to refer.

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  • Sán máng là một bệnh lý lây truyền qua môi trường nước nhiễm bệnh. Nó là loài đặc hữu ở các nước nhiệt đới và cận nhiệt đới chủ yếu là châu Phi và khu vực phía đông Địa Trung Hải.Kết quả giải phẫu bệnh xác định hình ảnh của sán máng (S. Haematobium) ở thành bàng quang đây là bệnh khá hiếm ở miền Bắc của Việt Nam. Ý nghĩa dịch tễ học và lâm sàng của hS. aematobium được thảo luận.

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