Sensitivity of measurement

Document "Constipation: A global perspective" introduction of content: Cascades—a resource-sensitive approach, pathogenesis and risk factors, associated conditions and medication, diagnostic criteria for functional constipation, patient evaluation,... Invite you to consult.

13p vovanvovan2013 13-05-2016 36 2   Download

2-Aminoethoxydiphenyl Borate (2-APB) has been extensively used recently as a membrane permeable modulator of inositol-1,4,5-trisphosphate-sensitive Ca2+ channels and store-operated Ca2+ entry. Here, we report that 2-APB is also an inhibitor of sarco/endoplasmic reticulum Ca2+ATPase (SERCA) Ca2+ pumps, and additionally increases ion leakage across the phospholipid bilayer. Therefore, we advise caution in the interpretation of results when used in Ca2+ signalling experiments.

10p system191 01-06-2013 40 4   Download

Liver microsomal preparations are routinely used to predict drug interactions that can occurin vivo as a result of inhi-bition of cytochrome P450 (CYP)-mediated metabolism. However, the concentration of free drug (substrate and inhibitor)at its intrahepatic site of action, a variable that cannot be directly measured, may be significantly different from that in microsomal incubation systems.

10p tumor12 20-04-2013 47 4   Download

NMR and visible spectroscopy coupled to redox measurements were used to determine the equilibrium thermodynamic properties of the four haems in cytochrome c3 under conditions in which the protein was bound to lig-ands, the small anion phosphate and the protein rubredoxin with the iron in the active site replaced by zinc.

10p awards 06-04-2013 37 4   Download

The information required for successful assembly of an icosahedral virus is encoded in the native conformation of the capsidproteinand in its interactionwith the nucleic acid. Here we investigated how the packing and stability of virus capsids are sensitive to single amino acid substitutions in the coat protein. Tryptophan fluorescence, bis-8-anilinonaph-thalene-1-sulfonate fluorescence, CD and light scattering were employed to measure urea- and pressure-induced effects on MS2 bacteriophage and temperature sensitive mutants. ...

11p dell39 03-04-2013 38 4   Download

Addresses: *The Van Andel Research Institute, 333 Bostwick, Grand Rapids, MI 49503, USA. †The University of Amsterdam, Department of Molecular and Cell Biology, 1081 BT Amsterdam, The Netherlands. ‡The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. §Yale University School of Medicine, Department of Pathology, 310 Cedar Street, New Haven, CT 06510, USA. Correspondence: Brian B Haab. E-mail: Brian.Haab@vai.

0p thulanh21 15-11-2011 55 1   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reproducibility and sensitivity to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval...

11p thulanh12 13-10-2011 51 3   Download