Serum iron

Hypochromic microcytic anemia (HMA) is a prevalent and serious condition if left untreated. Haemograms, serum iron, and ferritin tests play crucial roles in diagnosis and in guiding the identification of underlying causes. This study was conducted with the objective of describing the haemogram characteristics and assessing serum iron and ferritin levels in patients with hypochromic microcytic anemia.

6p viormkorn 27-09-2024 1 1   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 11 0   Download

Department of Chemistry ‘IFM’, University of Torino, Italy; 2Department of Biology, University ‘Roma Tre’, Rome, Italy; 3Department of Structural and Functional Biology, University of Insubria, Italy Haem binding to human serum albumin (HSA) endows the protein with peculiar spectroscopic properties. Here, the effect of ibuprofen and warfarin on the spectroscopic properties of ferric haem –human serum albumin (ferric HSA–haem) and of ferrous nitrosylated haem –human serum albumin (ferrous HSA –haem-NO) is reported.

7p system191 01-06-2013 46 3   Download

Although of major impact in terms of biological and environmental haz-ards, interactions of actinide cations with biological molecules are only par-tially understood. Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently con-tamination by actinide cations is a critical issue of nuclear toxicology. Combined X-ray absorption spectroscopy (XAS) and near infrared absorp-tion spectrometry were used to characterize a new complex between Tf and Np (IV) with the synergistic nitrilotriacetic acid (NTA) anion....

0p awards 06-04-2013 49 3   Download

Recent discoveries have indicated that the hormone hepcidin plays a major role in the control of iron homeostasis. Hepcidin regulates the iron level in the blood through the interaction with ferroportin, an iron exporter molecule, causing its internalization and degradation.

10p viettel02 22-02-2013 39 3   Download

Bệnh nhân 83 tuổi đàn bà, caucasian, trại nội thuơng hỏi ý kiến vì thiếu máu Hct 29%, MCV bình thuờng, MCH bình thường, Platelet bình thuờng (normocytic normochromic anemia), TB máu tráng 18 nghìn /mm3, nhưng bnhân đang uống Prednisone. Thử nghiệm gan, thận, LDH, Serum B12, Folate, Iron, TIBC, Ferritin, Protein electrophoresis, Serum immunofixation: normal, Nước đái: normal. Dòm phết máu dưới ống dầu (phóng đại 1000 lần): tb máu không thấy gì lạ, chỉ thấy hơi anisocytosis, poikilocytosis. Không thấy tb máu đỏ còn nhân (nucleated red cells). Bnhân uống Furosemide, Calcium channel blocker.

7p nganluong111 14-04-2011 79 3   Download

Deferasirox is a promising oral iron-chelating agent. Single daily doses of 20 or 30 mg deferasirox produced reductions in liver iron concentration comparable to desferoxamine in chronically transfused adult and pediatric patients. Deferasirox produces some elevations in liver enzymes and slight but persistent increases in serum creatinine, without apparent clinical consequence. Other toxicities are similar to those of desferoxamine. Its toxicity profile is acceptable, although long-term effects are still being evaluated.

6p thanhongan 07-12-2010 83 5   Download

Anemia of Acute and Chronic Inflammation/Infection (the Anemia of Chronic Disease) The anemia of chronic disease—which encompasses inflammation, infection, tissue injury, and conditions (such as cancer) associated with the release of proinflammatory cytokines—is one of the most common forms of anemia seen clinically and probably the most important in the differential diagnosis of iron deficiency, since many of the features of the anemia are brought about by inadequate iron delivery to the marrow, despite the presence of normal or increased iron stores.

5p thanhongan 07-12-2010 76 3   Download

Table 98-3 Iron Store Measurements Iron Stores 4+ Marrow Iron Stain, 0– µg/L Serum Ferritin, 0 0 150 Iron overload — 500–1000 Red Cell Protoporphyrin Levels Protoporphyrin is an intermediate in the pathway to heme synthesis. Under conditions in which heme synthesis is impaired, protoporphyrin accumulates within the red cell.

5p thanhongan 07-12-2010 68 2   Download

Assessment of Circulating (Visceral) Proteins The serum proteins most used to assess nutritional status include albumin, total iron-binding capacity (or transferrin), thyroxine-binding prealbumin (or transthyretin), and retinol-binding protein. Because they have differing synthesis rates and half-lives—the half-life of serum albumin is about 21 days whereas those of prealbumin and retinol-binding protein are about 2 days and 12 h, respectively—some of these proteins reflect changes in nutritional status more quickly than others.

6p konheokonmummim 03-12-2010 73 4   Download