Smooth muscle

Đề tài ngiên cứu nhằm mô tả các hình thái lâm sàng và giải phẫu bệnh của ung thư ống tiêu hóa không thuộc biểu mô; mô tả các phương pháp phẫu thuật và đánh giá kết quả điều trị phẫu thuật của ung thư ống tiêu hóa không thuộc biểu mô. Mời các bạn cùng tham khảo nội dung chi tiết.

197p badbuddy10 21-04-2022 14 4   Download

Mục tiêu của đề tài là mô tả các hình thái lâm sàng và giải phẫu bệnh của ung thư ống tiêu hóa không thuộc biểu mô; mô tả các phương pháp phẫu thuật và đánh giá kết quả điều trị phẫu thuật của ung thư ống tiêu hóa không thuộc biểu mô. Mời các bạn cùng tham khảo nội dung chi tiết.

27p badbuddy10 21-04-2022 19 1   Download

Viêm gan tự miễn (VGTM) là bệnh thường ít được nghĩ tới ở tình huống có tăng men gan, có dấu ấn huyết thanh của virus viêm gan (+) và xét nghiệm tự kháng thể ANA (-). Bệnh có thể gây xơ gan và thậm chí tử vong nếu không được chẩn đoán và điều trị. Tại bệnh viện Chợ Rẫy chúng tôi ghi nhận một số ca VGTM không điển hình với các đặc điểm nêu trên, đáp ứng tốt với với điều trị ức chế miễn dịch.

6p vihephaestus2711 25-09-2019 52 2   Download

The main contents of this chapter include all of the following: Force of muscle contraction, avelocity and duration of contraction, muscle fiber type, effects of exercise, effects of resistance exercise, the overload principle, smooth muscle, peristalsis, microscopic structure, innervation of smooth muscle,...and other contents.

47p tangtuy07 02-04-2016 40 4   Download

The main component of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease is the amyloid-b protein (Ab), a 4-kDa polypeptide derived from the b-amyloid protein precursor (APP). The accumulation of Ab in the basement membrane has been implicated in the degeneration of adjacent vascular smooth muscle cells (VSMC). However, the mechanism of Ab toxicity is still unclear. In this study, we examined the effect of substrate-bound Ab on VSMC in culture. The use of substrate-bound proteins in cell culture mimics presentation of the proteins to cells as if bound to the basement membrane.

9p system191 01-06-2013 42 5   Download

In this study, we isolated a 25-kDa novel snake venom protein, designated ablomin, from the venom of the Japanese Mamushi snake (Agkistrodon blomhoffi). The amino-acid sequence of this protein was determined by peptide sequencing and cDNA cloning. The deduced sequence showed high similarity to helothermine from the Mexican beaded lizard (Heloderma horridum horridum), which blocks voltage-gated calcium and potassium channels, and ryanodine receptors. Ablomin blocked contraction of rat tail arterial smooth muscle elicited by high K+-induced depolarization in the 0.

8p system191 01-06-2013 26 3   Download

The effect of a-tocopheryl hemisuccinate (TS) on lipopolysaccharide (LPS)/interferon-c (IFN)-induced nitric oxide production in rat vascular smooth muscle cells (VSMC) was examined. The LPS/IFN-induced NO production was enhanced by TS but not by the other a-tocopherol (a-T) derivatives a-tocopheryl acetate (TA) and a-tocopheryl nicotinate (TN), or a-T itself. a-T, TA and TN inhibited the enhancement by TS of LPS/IFNinduced NO production.

6p research12 01-06-2013 37 4   Download

TheDrosophila melanogasterprotein sprouty is induced uponfibroblast growth factor (FGF)- andepidermal growth factor (EGF)-receptor tyrosine kinase activation and acts as an inhibitor of the ras/MAP kinase pathway downstreamof these receptors. By differential displayRT-PCRof activated vs. resting umbilical artery smooth muscle cells (SMCs) we detected a new human sprouty gene, which we designated human sprouty 4 (hspry4) based on its homology with murine sprouty 4.

11p research12 29-04-2013 45 2   Download

Two neuropeptides have been isolated and identi®ed from the secretions of the skin glands of the Stony Creek Frog Litoria lesueuri. The ®rst of these, the known neuropeptide caerulein 1.1, is a common constituent of anuran skin secretions, and has the sequence pEQY(SO3 )TGWMDF-NH2 . This neuropeptide is smooth muscle active, an anal-gaesic more potent thanmorphine and is also thought to be a hormone.

10p research12 29-04-2013 41 3   Download

ADP-ribosylation has been coupled to intracellular events associated with smooth muscle cell vasoreactivity, cytoskel-etal integrity and free radical damage. Additionally, there is evidence that ADP-ribosylation is required for smooth muscle cell proliferation. Our investigation employed selective inhibitors to establish thatmono-ADP-ribosylation and not poly(ADP-ribosyl)ation was necessary for the sti-mulationofDNAsynthesis bymitogens.

10p tumor12 20-04-2013 23 2   Download

Activation of a calcium-sensing receptor (Ca-SR) leads to increased intracellular calcium concentration and altered cellular activities. The expression of Ca-SR has been iden-tified in both nonexcitable and excitable cells, including neurons and smooth muscle cells. Whether Ca-SR was expressed and functioning in cardiac myocytes remained unclear. In the present study, the transcripts of Ca-SR were identified in rat heart tissues usingRT-PCRthat was further confirmed by sequence analysis.

9p fptmusic 16-04-2013 48 2   Download

Calpain 1 behaviour toward cytoskeletal targets was inves-tigated using twoa-actinin isoforms from smooth and skel-etal muscles. These two isoforms which are, respectively, sensitiveandresistant tocalpaincleavage, interactwiththe protease when usinginvitro binding assays. The stability of the complexes in EGTA [Kd(–Ca2+)¼0.5 ± 0.1lM] was improved in the presence of 1 mMcalcium ions [Kd(+Ca2+)¼0.05 ± 0.01lM]. Location of the binding structures shows that the C-terminal domain ofa-actinin and each calpain subunit, 28 and 80 kDa, participates in the interaction....

9p fptmusic 12-04-2013 44 2   Download

In this study, we have characterized the influence of hypoxia on the expression of hydroxylases crucially involved in col-lagen fiber formation, such as prolyl-4-hydroxylases (Ph4) and procollagen lysyl-hydroxylases (PLOD). Using the rat vascular smooth muscle cell line A7r5, we found that an hypoxic atmosphere caused a characteristic time-dependent five- to 12-fold up-regulation of the mRNAs of the two P4h a-subunits [aI (P4ha1) andaII (P4ha2)] and of two lysyl-hydroxylases (PLOD1 and PLOD2).

8p fptmusic 12-04-2013 30 3   Download

Although group IIA secretory phospholipase A2 (sPLA2-IIA) is known to be abundantly present in the joints of patients with rheumatoid arthritis (RA), expression of other sPLA2 s in this disease has remained unknown. In this study, we examined the expression and localization of six sPLA2s (groups IIA, IID, IIE, IIF, V and X) in human RA.

18p awards 05-04-2013 40 4   Download

The proliferation of smooth muscle cells (SMC) is a key event in the development of atherosclerosis. In addition to growth factors or cytokines, we have shown previously that n-3 polyunsaturated fatty acids (PUFAs) act in opposition to n-6 PUFAs by modulating various steps of the inflam-matory process. We have investigated the molecular mech-anisms by which the incorporation of the n-6 PUFA, arachidonic acid, increases the proliferation of rat SMC treated with interleukin-1b, while the n-3 PUFAs eicosa-pentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit nomitogenic response. ...

0p awards 05-04-2013 57 3   Download

Connective tissue growth factor (CTGF/CCN2) is an immediate early gene-encoded polypeptide modulating cell growth and collagen synthesis. The importance of CTGF/ CCN2 function is highlighted by its disregulation in fibrotic disorders. In this study, we investigated the regulation and signaling pathways that are required for various stimuli of intracellular signaling events to induce the expression of the endogenous CTGF/CCN2gene in smooth muscle cells.

15p awards 05-04-2013 44 3   Download

We used differential scanning calorimetry (DSC) and circular dichroism (CD) to investigate thermal unfolding of recombinant fibroblast isoforms ofa-tropomyosin (Tm) in comparison with that of smooth muscle Tm. These two nonmuscle Tm isoforms 5a and 5b differ internally only by exons 6b⁄6a, and they both differ from smooth muscle Tm by the N-terminal exon 1b which replaces the muscle-specific exons 1a and 2a.

13p dell39 27-03-2013 39 3   Download

Expression of a previously cloned secretory protein named adrenocortical zonation factor 1 (AZ-1, also called Tin-ag-RP or lipocalin 7) is tightly linked with the zonal differentiation of adrenocortical cells. It is also pre-sent in vascular smooth muscle (VSM), although its function has remained unknown.

17p galaxyss3 21-03-2013 51 3   Download

In vascular smooth muscle cells and several other cell types, inhibition of Na + ⁄K + -ATPase leads to the expression of early response genes, including c-Fos. We designed this study to examine whether or not a putative Na + i ⁄K + i-sensitive element is located within the c-Fos5¢-UTR from )650 to +103 containing all known response elements activated by ‘classic’ stimuli, such as growth factors and Ca 2+ i-raising compounds.

11p galaxyss3 19-03-2013 35 3   Download

Osteopontin(OPN) is an arginine-glycine-aspartate (RGD)-contain-ing adhesive glycoprotein that was first identified as a major sialo-protein in bone and subsequently found to be expressed in kidney, brain, macrophages, vascular smooth muscle cells and many cells of epithelial linings. In this study we examined the expression of OPN in MDCK cells in different cellular confluences.

36p galaxyss3 19-03-2013 64 3   Download