Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression
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ADP-ribosylation has been coupled to intracellular events associated with smooth muscle cell vasoreactivity, cytoskel-etal integrity and free radical damage. Additionally, there is evidence that ADP-ribosylation is required for smooth muscle cell proliferation. Our investigation employed selective inhibitors to establish thatmono-ADP-ribosylation and not poly(ADP-ribosyl)ation was necessary for the sti-mulationofDNAsynthesis bymitogens.
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