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Specific hormone inhibitors
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Deregulated signal transducer and activator of transcription 3 (STAT3) signaling has been well documented in certain cancers. Alterations in specific negative regulators, such as protein inhibitor of activated STAT3 (PIAS3), may contribute to cancer development.
7p
vinaypyidaw2711
26-08-2020
12
1
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The release of phytosiderephores (PS) to the rhizosphere is the main root response to iron (Fe) deficiency in graminaceous plants.
14p
vichoji2711
29-04-2020
11
1
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Ecdysteroids are hormones with an important role in the molting, reproduction and immunological defense of arthropods. Ecdysone Receptor (EcR) is a protein that belongs to the superfamily of nuclear receptors, widely studied for pesticide discovery. Currently, several non-steroidal molecules, belonging to the chemical group of diacilhydrazines (DAH), are commercially available for pest control. Such molecules are specific for lepidopteran or coleopteran pests. Hemipterans are important pests in most crops and many cases of pesticide resistance are reported.
10p
chauchaungayxua1
04-12-2019
14
1
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Limited proteolysis is a highly specific irreversible process, which can serve to initiate physiological function by con-verting a precursor protein into a biologically active form. When the activating enzyme and the activated enzyme coincide, the process is an autocatalytic zymogen activation (i.e. reactions inwhich the zymogens serves as a substrate for the corresponding active enzyme). The activity of proteases is frequently regulated by the binding of specific protease inhibitors.
0p
awards
05-04-2013
32
1
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The reactive center loop (RCL) of serpins plays an essential role in the inhibition mechanism acting as a substrate for their target proteases. Chan-ges within the RCL sequence modulate the specificity and reactivity of the serpin molecule. Recently, we reported the construction of a1-antichymo-
10p
inspiron33
26-03-2013
33
3
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