![](images/graphics/blank.gif)
Specific mechanisms underlying
-
In recent years, there has been an increase in the incidence and mortality rates of prostate cancer (PCa). However, the specific molecular mechanisms underlying its occurrence and development remain unclear, necessitating the identification of new therapeutic targets.
10p
vishanshan
27-06-2024
2
1
Download
-
This article explores the evolving landscape of data protection law in Vietnam, focusing specifically on the responsibilities of data controllers under Vietnam's new Personal Data Protection Decree (Decree No. 13/2023/ND-CP - hereinafter referred to as Decree 13) and compares it with the European Union's General Data Protection Regulation (GDPR).
12p
viambani
18-06-2024
2
1
Download
-
Systemic sclerosis (SSc) is a multi-organ autoimmune disease characterized by skin fibrosis. Internal organ involvement is heterogeneous. It is unknown whether disease mechanisms are common across all involved affected tissues or if each manifestation has a distinct underlying pathology.
24p
vioraclene
31-03-2024
6
2
Download
-
"Standard Specification for Quenched and Tempered Alloy Steel Bolts, Studs, and Other Externally Threaded Fasteners" covers the chemical and mechanical requirements of quenched and tempered alloy steel bolts, studs, and other externally threaded fasteners 4 in. and under in diameter for application at normal atmospheric temperatures, where high strength is required and for limited application at elevated temperature. Any alloy steel capable of meeting the minimum mechanical and chemical properties set forth in this specification may be used.
7p
hth_hn_vn
10-12-2023
6
4
Download
-
"Standard Specification for Carbon and Ferritic Alloy Steel Forged and Bored Pipe for High-Temperature Service" covers heavy-wall carbon and alloy steel pipe made from turned and bored forgings and is intended for high-temperature service. Pipe ordered under this specification shall be suitable for bending and other forming operations and for fusion welding. Selection will depend on design, service conditions, mechanical properties and high temperature characteristics.
5p
hth_hn_vn
10-12-2023
6
4
Download
-
"Standard Specification for Pressure Vessel Plates, Alloy Steel, Chromium-Manganese-Silicon" covers chromium-manganese-silicon alloy steel plates, intended particularly for welded boilers and other pressure vessels. The maximum thickness of plates is limited only by the capacity of the composition to meet the specified mechanical property requirements; however, current practice normally limits the maximum thickness of plates furnished under this specification to 2 in. [50 mm].
3p
hth_hn_vn
10-12-2023
5
5
Download
-
"Standard Specification for Pressure Vessel Plates, Alloy Steel, Molybdenum" covers molybdenum-alloy steel plates, intended particularly for welded boilers and other pressure vessels. The maximum thickness of plates is limited only by the capacity of the composition to meet the specified mechanical property requirements; however, current practice normally limits the maximum thickness of plates furnished under this specification.
3p
hth_hn_vn
10-12-2023
14
4
Download
-
This specification covers stainless steel floor plates ½ in. and under for use in galley spaces, washrooms, engine rooms, and machinery spaces, and for ladder treads, gun platforms, and deck treads. For these uses, Patterns A, B, and C are considered interchangeable.
4p
hth_hn_vn
10-12-2023
10
4
Download
-
High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in ovarian cancer (OV) remain markedly unknown.
13p
vischultz
20-10-2023
1
1
Download
-
Ebook "AIAA aerospace design engineers guide (5th edition)" is a revised and enlarged version of the previous edition. It has been prepared under the charter of the AIAA Design Engineering Technical Committee to assist the design engineer in creating and defining practical aerospace products. The intended scope of this guide is to provide a condensed collection of commonly used engineering reference data and to also function as a general reference guide for disciplines related specifically to aerospace design.
437p
tieulangtran
28-09-2023
2
1
Download
-
The expression of genes involved in regulating adipogenesis and lipid metabolism may affect economically important fatness traits in pigs. Allele-specific expression (ASE) reflects imbalance between allelic transcript levels and can be used to identify underlying cis-regulatory elements.
9p
vihagrid
30-01-2023
6
3
Download
-
Glucocorticoids are commonly used in the clinical setting for their potent anti-inflammatory effects; however, significant variations in response to treatment have been demonstrated. Although the underlying mechanisms have yet to be fully understood, this variable response may be a result of alterations in human glucocorticoid receptor (hGR) expression and function.
15p
vihagrid
30-01-2023
5
3
Download
-
Identifying genetic variants that are associated with methylation variation—an analysis commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important for understanding the epigenetic mechanisms underlying genotype-trait associations.
18p
vielonmusk
30-01-2022
15
0
Download
-
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification. However, it is not fully understood how individual stem cells exit the pluripotent state and transition towards their respective progenitor states.
20p
viaristotle
29-01-2022
7
0
Download
-
Recent evidence suggests that RNA interaction can regulate the activity and localization of chromatin-associated proteins. However, it is unknown if these observations are specialized instances for a few key RNAs and chromatin factors in specific contexts, or a general mechanism underlying the establishment of chromatin state and regulation of gene expression.
18p
viaristotle
29-01-2022
13
0
Download
-
Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified.
39p
viarchimedes
26-01-2022
10
1
Download
-
Plants evolved from long-term adaptation to form regulatory mechanisms of perception, transduction, and response to stresses. The CBL–CIPK signaling system is a basic calcium sensor that plays an important role in sensing adverse environmental stimuli. CBLs can perceive and bind Ca2+ under adversity and then specifically interact with CIPKs. The activated CBL–CIPK complex phosphorylates downstream target proteins (such as ion channels and transporters), or regulates transcription factors and stress responsive genes.
10p
tudichquannguyet
29-11-2021
8
1
Download
-
The therapeutic management of obesity is challenging, hence further elucidating the underlying mechanisms of obesity development and identifying new diagnostic biomarkers and therapeutic targets are urgent and necessary. Here, we performed differential gene expression analysis and weighted gene co-expression network analysis (WGCNA) to identify significant genes and specific modules related to BMI based on gene expression profile data of 7 discordant monozygotic twins.
17p
vilarryellison
29-10-2021
15
0
Download
-
The outcome of cervical artificial insemination (AI) with frozen-thawed semen in sheep is limited by the inability of sperm to traverse the cervix of some ewe breeds. Previous research has demonstrated that cervical sperm transport is dependent on ewe breed, as sperm can traverse the cervix in greater numbers in some higher fertility ewe breeds. However, the molecular mechanisms underlying ewe breed differences in sperm transport through the cervix remain unknown.
11p
vilarryellison
29-10-2021
11
0
Download
-
Current heart failure (HF) treatment is based on targeting symptoms and left ventricle dysfunction severity, relying on a common HF pathway paradigm to justify common treatments for HF patients. This common strategy may belie an incomplete understanding of heterogeneous underlying mechanisms and could be a barrier to more precise treatments. We hypothesized we could use RNA-sequencing (RNA-seq) in human heart tissue to delineate HF etiology-specific gene expression signatures.
14p
vitzuyu2711
29-09-2021
11
1
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)