Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in ovarian cancer (OV) remain markedly unknown.