Sprague Dawley rats

This study aimed to evaluate effects of electric vagal nerve stimulation on early postoperation cognitive dysfunction in aged rats. Methods: A total of 33 male Sprague Dawley rats were selected and assigned randomly to three groups, control group (C, n = 10), splenectomy group (S, n = 10) and splenectomy+vagal nerve stimulation group (SV, n = 13).

11p vizhangzhidong 29-12-2021 4 0   Download

Obesity is an important public health problem and a risk factor for many chronic diseases, and its prevalence is increasing rapidly. In recent years there has been interest in the impact of nutrients on obesity and this has been addressed as a research topic. Bee bread is a bee product that has recently attracted attention with its macro- and micronutrients and the enzymes and biocomponents it contains. Although there are many studies on the biological properties and effects of bee bread, its effect on obesity with leptin and ghrelin has not been investigated.

12p dolomite36 30-12-2021 13 0   Download

The experiment was conducted in order to investigate the antitumor, antiproliferative and antiangiogenic activity of citrus bioflavonoid, the hesperidin (HES), on N-methlyN-nitrosourea (MNU) induced mammary tumors in Sprague-Dawley (SD) rats with reference to histopathology and immunohistochemical expressions of PCNA, Ki-67 and VEGF markers.

12p chauchaungayxua12 29-07-2021 18 1   Download

Heat stress (HS) is a major stress event in the life of an animal, with detrimental upshots in production and health. Long-non-coding RNAs (lncRNAs) play an important role in many biological processes by transcriptional regulation.

16p vilichoo2711 23-06-2021 15 1   Download

Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain.

9p vivermont2711 28-01-2021 14 1   Download

With the aim to explore the anti-tumour effect of Withaferin A in DMBA (7,12- dimethylbenz[a]anthracene) induced mammary tumour in rats, seventy two female Sprague-Dawley rats were equally distributed to control, DMBA, tamoxifen and Withaferin A groups. Tamoxifen, which is widely used as first-line drug in the treatment of estrogen positive breast cancer was taken as standard for comparison. The study was conducted for a period of 16 weeks. DMBA (5 mg/rat/week/per os) at 4 weekly doses were used for tumour induction. Piloerection was noticed after DMBA administration.

10p caygaocaolon7 18-09-2020 20 0   Download

The study was undertaken for 150 days on female Sprague-Dawley rats to evaluate antioxidant effects on DMBA induced mammary tumours. A total of 80 rats were randomly allotted to 5 groups with 18 rats in 4 groups and 12 rats to the control group distributed to DMBA, DMBA + Tamoxifen and DMBA + Idivallathi mezhugu (IM) and IM groups. Rats were administered with 4 weekly doses of 5 mg DMBA/rat in olive oil by oral gavage beginning at 42nd day of age.

5p kethamoi7 26-08-2020 5 1   Download

The present study was carried out on Sprague Dawley rats to evaluate the sub-acute toxicity of an anti - tumor necrosis factor -alpha receptor fusion protein named etanercept. Etanercept is a biopharmaceutical compound and is the first anti-tumor necrosis factor agent to be approved for the treatment of rheumatoid arthritis.

17p nguaconbaynhay7 15-08-2020 9 1   Download

Antidepressant, Phenothiazine, QSAR, Antidepressants are the drugs used to treat depression thereby elevates mood and modifies the behavior. The main aims in the development of new antidepressants were greater efficacy, absence of side effects, lack of toxicity in over dose and earlier onset of action. In this study, a series of novel substituted phenothiazine was synthesized and evaluated for antidepressant activity by using or forced swim test (FST). Our synthetic route started from substituted aniline which was reacted with cyclohexanone.

8p nguaconbaynhay6 24-06-2020 10 0   Download

The present study was undertaken on 60 adult female Sprague Dawley rats (275±2.04 g) for an experimental duration of 84 days to evaluate various organic sources of zinc on immunity, reproduction, oxidative defense mechanism in rats. The rats were randomly allotted to 5 dietary treatments (6 replicates in each) prepared by varying the source of Zn supplementation (12 ppm) either from inorganic (Zn carbonate) or sources (Zn proteinate, Zn propionate, Zn amino acid complex and Zn methionine).

11p nguaconbaynhay6 24-06-2020 8 0   Download

Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a limited number of tyrosine kinases. It is currently registered in Europe and USA for the treatment of mast cell tumors in dogs.

18p vijiraiya2711 27-05-2020 6 0   Download

Basic function of bromine in body is to activate pepsin production in gastritis with low acidity. The present study encompasses a broad in vivo study to evaluate gastroprotective activity of a novel dibromo substituted Schiff base complex against Sprague Dawley (SD) rats.

13p vimax2711 30-03-2020 10 2   Download

This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male Sprague Dawley (SD) rats.

9p vimax2711 30-03-2020 30 1   Download

The major purpose of our study is to evaluate the impact of cinnamon on long term prediabetic induced renal alterations caused by intraperitonial induction of neonatal streptozotocin (nSTZ). Two-day old male Sprague Dawley (SD) rat pups (n=30) received a single intra peritoneal injection of STZ (90 mg/kg bw) dissolved in 0.1M citrate buffer, pH 4.5 while Control pups (n=8) received the vehicle alone. All rats were maintained on an AIN-93G/M diet in individual cages and a subset of pre-diabetic animals received 3% cinnamon in the AIN-93 diet.

8p nguaconbaynhay1 04-12-2019 30 0   Download

Cardiac hypertrophy is an independent predictor of cardiovascular morbidity and mortality. To identify the mechanisms by which simvastatin inhibits cardiac hypertrophy induced by pressure overload, we determined effects of simvastatin on 14-3-3 protein expression and autophagic activity.

9p vihasaki2711 12-11-2019 11 1   Download

The present study aimed to examine the effects of the types of high-calorie diets (high-fat and high-fathigh-sucrose diets) and two different developmental stages (post-weaning and young adult) on the induction of metabolic syndrome. Male, post-weaning and adult (3- and 8-week old, respectively) Sprague Dawley rats were given control, high-fat (60% kcal), and high-fat-high-sucrose (60% kcal fat + 30% sucrose water) diets for eight weeks (n = 6 to 7 per group). Physical, biochemical, and transcriptional changes as well as liver histology were noted.

10p trinhthamhodang1 14-11-2019 10 0   Download

Cataracts are the major cause of blindness and are associated with oxidative damage of the lens. In the present study, the aim was to evaluate the protective effects of rosmarinic acid on selenite-induced cataractogenesis in Sprague-Dawley rat pups.

12p vinasaki2711 12-11-2019 13 1   Download

The effects of cold exposure and cold plus phenoxybenzamine treatment on tyrosine hydroxylase (TH) activity and TH m RNA levels were investigated in the adrenal medulla of Sprague Dawley (SD) rats. SD rats were exposed to cold (4 °C) for 48 hours.

8p vitamix 19-02-2019 25 0   Download

The aim of the present study was to investigate the effects of a sublethal dose of trichloroacetic acid (TCA) on serum enzyme levels and erythrocyte carbonic anhydrase (CA) activity in rats under laboratory conditions. Ten Sprague-Dawley albino rats were divided in 2 groups of 5 rats.

5p vitamix 15-02-2019 14 0   Download

This study was carried out to investigate whether plant growth regulators (PGRs) could affect lipid peroxidation (Malondialdehyde = MDA level) in erythrocyte, muscle, liver, heart and kidney tissue. Eighteen Sprague-Dawley albino rats were divided into three experimental groups: control and PGR-treated (indoleacetic acid and kinetin).

4p vitamix 15-02-2019 31 1   Download