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Stage IV
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Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/carboplatin+bevacizumab a common chemotherapy regimen for stage IV non-squamous NSCLC; however, primary or acquired resistance to paclitaxel is gradually increasing, leading to treatment failure.
13p
vikoch
27-06-2024
2
1
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presents the following content: Chapter I: to deliver you from the preliminary terrors; Chapter II: on different degrees of smallness; Chapter III: on relative growings; Chapter IV: simplest cases; Chapter V: next stage: what to do with constants; Chapter VI: sums, differences, products, and quotients; Chapter VII: successive differentiation; Chapter VIII: when time varies; Chapter IX: introducing a useful dodge; Chapter X: geometrical meaning of differentiation;…
296p
zizaybay1103
29-05-2024
4
2
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Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations. Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.
5p
viohoyo
02-04-2024
7
2
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A deep understanding of potential molecular biomarkers and therapeutic targets related to the progression of colorectal cancer (CRC) from early stages to metastasis remain mostly undone. Moreover, the regulation and crosstalk among diferent cancer-driving molecules including messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs) and micro-RNAs (miRNAs) in the transition from stage I to stage IV remain to be clarified, which is the aim of this study
22p
vimichaelfaraday
28-12-2023
5
4
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Systemic inflammation is currently regarded as a hallmark of cancer. This study aimed to accurately clarify the prognostic value of various inflammatory markers in patients with stage IV cancer.
11p
vialfrednobel
23-12-2023
4
3
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To evaluate long-term results of treatment for avascular necrosis of femoral head in late stages by using Spiron total hip replacement. Subject and method: From 2012 to 2016, 68 patients who are not older than 50 with stage IV, V, VI of avascular necrosis (According to Steinberg classification) were treated by 90 Spiron hips replacement in the Institute of Trauma and Orthopedic - 108 Military Central Hospital.
6p
visoros
01-11-2023
5
1
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To investigate the prognostic impact of the controlling nutritional status (CONUT) score in non-small cell lung cancer (NSCLC) patients receiving first-line chemotherapy. CONUT score is an independent prognostic indicator of poor outcomes for patients with stage III-IV NSCLC and is superior to the SII and PNI in terms of prognostic ability.
10p
vischultz
20-10-2023
3
1
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This study was designed to investigate the impact of age on the effectiveness and immune-related adverse events (irAEs) of programmed death-(ligand)1 [PD-(L)1] inhibitors in patients with non-small cell lung cancer (NSCLC) using a novel text-mining technique.
12p
vischultz
20-10-2023
5
1
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Pulmonary large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) are two types of high-grade neuroendocrine carcinomas of the lung with poor prognosis. LCNEC has not been thoroughly studied due to its rarity, data are also lacking regarding the survival comparison and prognosis analysis of patients with locally advanced or metastatic LCNEC and SCLC.
17p
vischultz
20-10-2023
2
1
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With more than 15,000 new cases /year in France and 2,000 deaths, cutaneous melanoma represents approximately 4% of incidental cancers and 1.2% of cancer related deaths. In locally advanced (stage III) or resect‑ able metastatic (stage IV) melanomas, medical adjuvant treatment is proposed and recent advances had shown the benefit of anti-PD1/PDL1 and anti-CTLA4 immunotherapy as well as anti-BRAF and anti-MEK targeted therapy in BRAF V600 mutated tumors.
11p
visharma
20-10-2023
4
2
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We aimed to examine whether patients with de novo and relapsed/progressed stage IIIB–IV non-small cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutations have different prognoses.
12p
visharma
20-10-2023
6
2
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Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated. Methods This retrospective study used propensity score matching (PSM). The clinical case data of 1470 patients with surgically treated stage I–IV CRC at Wuhan Union Hospital were collected.
16p
visharma
20-10-2023
8
2
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The goal of therapy for many patients with advanced stage malignancies, including those with metastatic gastric and esophageal cancers, is to extend overall survival while also maintaining quality of life. After weighing the risks and benefts of treatment with palliative chemotherapy (PC) with non-curative intent, many patients decide to pursue treatment.
9p
vioracle
29-09-2023
5
3
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Pulmonary pleomorphic carcinoma is a very rare histological type of primary lung cancer, and usually provides aggressive clinical courses. A 65-year-old Japanese woman was diagnosed by transbronchial biopsy of the primary tumor as c-stage IV (cT4N3M1b) of adenocarcinoma harboring L858R point mutation in the exon 21 of epidermal growth factor receptor (EGFR).
5p
viintuit
26-09-2023
3
0
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Nivolumab is a checkpoint inhibitor approved to treat various solid organs malignancies. Although checkpoint inhibitors are very efficacious, these medications are also associated with a variety of side effects that could be life-threatening. We present a case of nivolumab-induced myasthenia gravis in a patient with stage IV esophageal cancer, who was found to have generalized weakness, blurry vision, diplopia, and later developed acute hypoxic respiratory failure with subsequent intubation.
5p
viintuit
26-09-2023
1
0
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To Determine Prognostic factors for overall survival in patients with metastatic gastric cancer (mGC). Methods: A retrospective descriptive study on patients with stage IV gastric cancer in the Oncology Center of Hue central hospital, Viet Nam, from 2015 to 2020. Before initiating treatment, demographic, clinical, and laboratory features as well as treatment methods were documented.
5p
vinebula
02-06-2023
4
2
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Ebook Knowledge management systems: Value shop creation – Part 1 presents the following content: Section I: Introduction and background, Chapter I: Value shop configuration, Chapter II: Knowledge management, Chapter III: Knowledge management systems, Chapter IV: Knowledge technology stages, Section II: Knowledge-intensive value shop activities, Chapter V: E-business knowledge. Please refer to the documentation for more details.
131p
runthenight08
12-04-2023
6
1
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Soft tissue sarcomas (STSs) are a heterogeneous group of cancers with over 100 described subtypes. While these cancers are infrequent, the prognosis is quite poor, particularly for those with stage IV metastatic disease.
11p
vikolindagrabar
27-07-2022
4
1
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The 8th edition UICC/AJCC TNM8 (Tumour, Nodes, Metastasis) melanoma staging system introduced several modifications from the 7th edition (TNM7), resulting in changes in survival and subgroup composition. We set out to address the limited validation of TNM8 (stages I-IV) in large population-based datasets.
11p
vikolindagrabar
27-07-2022
4
1
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Papillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for advanced stage IV medullary and for anaplastic tumours are limited. Recently, somatostatin receptors (SSTs) and the chemokine receptor CXCR4 have been evaluated for the treatment of thyroid carcinomas, however, with contradictory results.
17p
vikolindagrabar
27-07-2022
5
1
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