Stromal cells
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Ebook "Prostate cancer: Biochemistry, molecular biology and genetics" provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.
517p tracanhphuonghoa1007 22-04-2024 2 2 Download
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Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the various non-cancer cellular elements intertwined with cancer cells in the tumor microenvironment.
22p vibransone 28-03-2024 2 2 Download
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Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular composition of the tumor microenvironment is critical to the understanding of the disease and treatment of the patient.
14p vibransone 28-03-2024 4 2 Download
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Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies.
15p vibransone 28-03-2024 3 2 Download
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High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characterisation of this heterogeneity, but the lack of strong prognostic or predictive correlations with these subtypes currently hinders their clinical implementation.
30p vibransone 28-03-2024 6 2 Download
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Ebook "Mesenchymal stem cells: Basics and clinical application I" provides readers with contents including: prospective isolation and characterization of human bone marrow-derived MSCs; urine as a source of stem cells; expansion of mesenchymal stem/stromal cells under xenogenic-free culture conditions; adipose-derived mesenchymal stem cells - biology and potential applications;...
198p coduathanh1122 27-03-2024 2 1 Download
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Ebook "Mesenchymal stromal cells: Biology and clinical applications" have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.
697p duongthandue0501 28-02-2024 3 1 Download
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Human bone marrow stromal cells (BMSCs) are an easily accessible and expandable progenitor population with the capacity to generate neural cell types in addition to mesoderm. Lineage tracing studies in transgenic animals have indicated Nestin+BMSCs to be descended from the truncal neural crest.
12p vicwell 29-02-2024 5 1 Download
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Ebook "Adult stem cells: Methods and protocols" contains a collection of protocols from some of the major laboratories involved in stem cell research across the world. The research discussed in this book covers topics such as: isolating, characterizing and expanding dental pulp stem cells; manipulating the proliferative potential of cardiomyocytes by gene transfer; isolation of stromal stem cells from adipose tissue; noninvasive assessment of cell fat and biology in transplanted mesenchymal stem cells; and cell-free therapy for organ repair.
320p lamquandat 28-12-2023 5 2 Download
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Single-cell RNA sequencing (scRNA-seq) enables the systemic assessment of intratumoral heteroge‑ neity within tumor cell populations and in diverse stromal cells of the tumor microenvironment. Gain of treatment resistance during tumor progression or drug treatment are important subjects of tumor-centric scRNA-seq analyses, which are hampered by scarce tumor cell portions.
10p vileonardodavinci 23-12-2023 3 2 Download
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The malignant behaviors of lung cancers are affected by not only cancer cells but also many kinds of stromal cells in tumor microenvironment (TME), including macrophages. Macrophages have been proven to extensively influence tumor progression through several mechanisms, among which switching of macrophages from proinflammatory phenotypes (M1-like) to anti-inflammatory phenotypes (M2-like) mediated by transcription factors such as nuclear factor κB (NF-κB) is the most crucial event. The regulation of NF-κB has been well studied, however some details remain fuzzy.
18p vileonardodavinci 23-12-2023 3 2 Download
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Most patients diagnosed with head and neck tumor will present with locally advanced disease, requiring multimodality therapy. Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived signals, such as inflammatory cytokines and growth factors.
10p vileonardodavinci 23-12-2023 6 2 Download
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Cells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA) compartment and terminally differentiated (TD) compartment. Maturation of stem cells is characterized by epithelial stromal interaction and sequential maturational movement of stem cell’s progeny through those compartments.
16p vischultz 20-10-2023 3 1 Download
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Cancer’s hallmark feature is its ability to evolve, leading to metastasis and recurrence. Although genetic mutations and epigenetic changes have been implicated, they don’t fully explain the leukocytic traits that many cancers develop. Cell fusion between cancer and somatic cells, particularly macrophages, has been suggested as an alternative pathway for cancer cells to obtain new traits by acquiring exogenous genetic material.
13p visharma 20-10-2023 5 2 Download
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Most testicular tumors are germ cell tumors; sex cord stromal tumors are infrequent, accounting for only 3–5% of testicular tumors. Unclassifed sex cord stromal tumors are extremely rare. Generally, 10% of sex cord stromal tumors are malignant. We report a case of malignant unclassified sex cord stromal tumor with retroperitoneal lymph node metastasis at first visit and a corresponding literature review.
6p vigamora 23-05-2023 5 2 Download
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Granulosa tumor is a rare tumor that arises from the mesenchyme and the sexual cord of the ovary. The prognosis is generally excellent, and treatment is mainly based on surgery, followed by chemotherapy depending on the extension of the disease. However, “the obstetrical prognosis” is compromised.
6p videadpool 05-05-2023 3 2 Download
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Ovarian steroid cell tumors, not otherwise specified is a rare sex cord-stromal tumor. Almost 60% of all steroid cell tumors are categorized as not otherwise specified and represent less than 0.1% of all ovarian neoplasm.
4p videadpool 05-05-2023 4 2 Download
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Differentiation of Immortalized Human Bone Marrow Mesenchymal Stromal Cells - hTERT (iMSC3) into adipocytes is in vitro model of obesity. In our earlier study, rosiglitazone enhanced adipogenesis particularly the brown adipogenesis of iMSC3.
18p vihagrid 30-01-2023 6 3 Download
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Part 1 of ebook "Focus on gynecologic malignancies" provide readers with content about: epidemiologic evidence for the obesity-endometrial cancer relationship; epidemiologic relationship between obesity and ovarian cancer; public knowledge of obesity and gynecologic cancer risk; role of estrogen and progesterone in obesity associated gynecologic cancers; obesity and endometrial cancer precursors;... Please refer to the ebook for details!
173p tieuduongchi 24-10-2022 3 2 Download
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Periostin is an extracellular matrix protein that has been known to be implicated in fibrillogenesis and cell migration, including cancer metastasis. Periostin overexpression in cancer cells and/or intervening stroma is usually related to tumor progression and poor patient outcomes in various human cancers; however, its role in urothelial carcinoma, especially upper urinary tract urothelial carcinomas (UTUCs), remains inconclusive.
10p vikolindagrabar 27-07-2022 2 2 Download