Structural conformation

Part 1 book "Advanced organic chemistry" includes contents: Chemical bonding and molecular structure; stereochemistry, conformation, and stereoselectivity; structural effects on stability and reactivity; nucleophilic substitution; polar addition and elimination reactions.

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Ebook "Topology in molecular biology: DNA and proteins" presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology.

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In ebook "Single-molecule fluorescence spectroscopy of the folding of a repeat protein" single-molecule fluorescence resonance energy transfer (FRET) spectroscopy was used to study the folding of a protein that belongs to the large and important family of repeat proteins. Cohen shows that the dynamics of the expanded conformations is likely to be very fast, suggesting a spring-like motion of the whole chain. The findings shed new light on the elasticity of structure in repeat proteins, which is related to their function in binding multiple and disparate partners.

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Ebook "CFTR and cystic fibrosis: From structure to function" is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.

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Current computational methods on Hi-C analysis focused on identifying Mb-size domains often failed to unveil the underlying functional and mechanistic relationship of chromatin structure and gene regulation. We developed a novel computational method HiSIF to identify genome-wide interacting loci.

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Ebook "Raman spectroscopy of conformational rearrangements at low temperatures: Folding and stretching of alkanes in supersonic jets" identifies the turning point in chain length, after which alkanes self-solvate into a folded structure instead of an extended stretched conformation. After this turning point, London dispersion forces rearrange isolated n-alkanes into a particular hairpin-structure, while for shorter chain lengths, a simple stretched conformation is energetically preferred.

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Ebook "Dynamics in enzyme catalysis (Topics in Current chemistry, Volume 337)" provides readers with contents including: relationship of femtosecond–picosecond dynamics to enzyme-catalyzed H-transfer; protein conformational disorder and enzyme catalysis; a surprising role for conformational entropy in protein function; structured crowding and its effects on enzyme catalysis;...

217p coduathanh1122 27-03-2024 1 1   Download

Ebook "Molecular chaperones (Topics in Current chemistry, 328)" describes all three families of known peptidyl prolyl isomerases (PPIases) including the FKBPs, cyclophilins and parvulins. These chaperones catalyse conformational interconversions of peptide bonds which can be critical to the correct folding of many proteins. The structural and chemical features of PPIases and the catalytic cycle are described, and a discussion of chaperoning versus catalysis is also included.

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Ebook "A guide to biomolecular simulations (Focus on structural biology, Volume 4)" tries to fill this need. The Guide consists of six chapters which provide the fundamentals of the field and six chapters which introduce the reader to more specialized but important applications of the methodology.

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This paper presents a novel formulation for static limit analysis of structures, for which the Airy stress function is approximated using stabilized Radial Point Interpolation Meshfree method (RPIM).

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Ebook "NMR in biological systems: From molecules to humans" caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.

552p tachieuhoa 28-01-2024 8 2   Download

This specification covers steel track spikes used as fastenings between railroad rails, tie plates, and ties; Three grades of spikes are described, Grades 1, a lower carbon steel; Grade 2, a higher carbon steel; and Grade 3, a carbon structural steel, conforming to Specification A36/ A36M.

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This specification covers three types and five strength grades of high-strength low-alloy, hot rolled structural steel plate for use in truck frames, brackets, crane booms, rail cars, and similar applications. Steels that conform to this specification offer improved formability. These steels are normally furnished in the as-rolled condition. The type and strength grade furnished is as agreed upon between the manufacturer and the purchaser. The types and strength grades are shown in the tables.

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Ebook "Polymer chemistry (Second edition)" provides a well-rounded and articulate examination of polymer properties at the molecular level. It focuses on fundamental principles based on underlying chemical structures, polymer synthesis, characterization, and properties. Consistent with the previous edition, the authors emphasize the logical progression of concepts, rather than presenting just a catalog of facts.

597p loivantrinh 29-10-2023 7 2   Download

Ebook "The physics of polymers: Concepts for understanding their structures and behavior" presents the elements of this important branch of materials science in the style of a series of lecture. The main focus lays on the concepts, rather than on experimental techniques and theoretical methods. Written for graduate students of physics, materials science and chemical engineering, as well as for researchers in academia and industry entering this field, the book introduces and discusses the basic phenomena that lead to the peculiar physical properties of polymeric systems.

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In tissue engineering, coating biomaterial’s surface with extracellular matrix (ECM) proteins can promote many biological activities, including cellular responses, wound healing, and rejection reduction. Several interactions occur upon binding proteins onto the surfaces, leading to changes in the protein structural conformation, directly affecting the cell-host interactions. Therefore, this study investigates the impacts of surfaces’ wettability on protein conformation.

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Part 1 of ebook "Advanced organic chemistry - Part A: Structure and Mechanisms" has presents the following content: chemical bonding and molecular structure; stereochemistry, conformation, and stereoselectivity; structural effects on stability and reactivity; nucleophilic substitution; polar addition and elimination reactions; carbanions and other carbon nucleophiles;...

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In this Masters thesis computational modelling techniques were employed to investigate iron-free apo-Lactoferrin (apo-Lf) structural conformation changes in the presence of variant temperature and pH. These conditions represent the environment most milk protein goes through in food processing and the production of food products.

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The combination of four iso-nicotinate appended tetrathiacalix[4]arene (TCA-1) in 1,2-alternate imposed conformation behaving as neutral tectons with Co(II)Cl2 and Hg(II)Cl2 metallic salts, leads to the formation of neutral, new coordination networks. Indeed, the tetrasubstituted TCA-1 derivative leads to a 1D coordination polymer with Co(II)Cl2 and a 2D grid-like network with, Hg(II)Cl2 . The effect of the nature of the metal used on the dimensionality was demonstrated by X-ray diffraction studies on a single crystal.

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New ligand based on p-tertbutyltetrathiacalix[4]arene blocked in 1,3-alternate conformation, was achieved via a multistep synthesis with the introduction of thiomethylpropoxy groups on the lower rim which leads to a neutral tecton. The combination of this p-tertbutyltetrathiacalix[4]arene (p-TCA-2), in 1, 3-alternate imposed conformation, with tetrahedral Ag(I)SbF6 salt, leads to the formation of neutral, new 2-D coordination network, which was structurally investigated in the solid state by X-ray diffraction methods on a single crystal.

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