![](images/graphics/blank.gif)
Switching activity
-
Ebook "Mitochondria and cancer" presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins.
294p
ladongphongthanh1008
22-04-2024
4
1
Download
-
Aromatase inhibitors (AI) are frequently used to treat hormone-receptor-positive breast cancer, but they have multiple adverse effects (e.g., osteoporosis, arthralgia), resulting in premature therapy discontinuation/ switch. Physical activity (PA) can attenuate these negative effects and improve quality of life (QoL).
17p
vioracle
29-09-2023
7
2
Download
-
This work also supports the idea of altering the electrical conductivity of sensors and enhancing the response and selectivity of NO2 gas sensing devices using visible light as light-activated gas sensors, which would create new opportunities for specialised NO2 sensors.
13p
viberbers
09-08-2023
3
3
Download
-
Myogenic Differentiation 1 (MyoD) is a crucial master switch in regulating muscle-specific gene transcription. Forced expression of myoD is equipped to induce several cell lineages into myoblast, which then differentiate and fuse into myotube. Pig is one of the most significant livestock supplying meat, and has been classified into lean, fat and miniature pig breeds.
11p
vihagrid
30-01-2023
9
3
Download
-
Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticarcinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active compound, trans-p-coumaric acid (p-CA), on human colon cancer cells (DLD-1, HT-29, SW-620, Caco-2) and healthy colon epithelial cells (CCD-18Co).
12p
thiencuuchu
27-11-2021
4
0
Download
-
This paper considers an application of the Markov switching vector error correction model to the analysis of the long-run and the short-run dependence of Russian real GDP and real exchange on oil prices. An algorithm for estimation of the model with a priori information on a state of hidden Markov chain in some periods of time is provided.
11p
caygaocaolon11
18-04-2021
21
2
Download
-
Given the development of high-throughput experimental techniques, an increasing number of whole genome transcription profiling time series data sets, with good temporal resolution, are becoming available to researchers.
11p
viflorida2711
30-10-2020
33
2
Download
-
ErbB4/HER4 is a unique member of the ErbB family of receptor tyrosine kinases concerning its activation of anti-proliferative JAK2-STAT5 pathway when stimulated by ligand Neuregulin (NRG). Activation of this pathway leads to expression of genes like β-casein which promote cell differentiation.
14p
vijisoo2711
27-10-2020
5
0
Download
-
In breast cancer, progesterone receptor (PR) positivity or abundance is positively associated with survival and treatment response. It was initially believed that PR was a useful diagnostic marker of estrogen receptor activity, but increasingly PR has been recognised to play an important biological role in breast homeostasis, carcinogenesis and metastasis.
17p
vimoscow2711
29-08-2020
51
1
Download
-
Cancer metastasis is one of the most common causes of treatment failure and death in cancer patients. It has been acknowledged that aberrant activation of epithelial-to-mesenchymal transition (EMT) program, endows cancer cells with metastatic competence for which E-cadherin switch is a well-established hallmark.
18p
vinaypyidaw2711
26-08-2020
23
2
Download
-
Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch regions of Rac1 to prevent access from GEFs.
11p
vibaku2711
22-07-2020
14
1
Download
-
Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear. This work aimed to reveal whether Ras-ERK1/2 promoted the development of colorectal cancer via regulating H3K9ac.
10p
viputrajaya2711
22-06-2020
21
1
Download
-
Using a Bluetooth connection will reduce the use of cables and speed up the process of activating or deactivating electronic devices because they do not have to get close to reach the switch. With input in the form of voice commands is very easy in controlling electronic devices such as fans and lights. With the adjustment of the fan speed and brightness of the lights with voice commands can save electricity and more easily in its settings.
9p
lucastanguyen
28-05-2020
21
1
Download
-
Generic drugs may help to support antiretroviral treatment. We want to assess the efficacy and safety at 24 weeks of the change of coformulated (abacavir + lamivudine + dolutegravir) to (abacavir + lamivudine) coformulated as a generic pharmaceutical specialty + dolutegravir.
4p
vimax2711
30-03-2020
9
0
Download
-
The protein deacetylase sirtuin 1 (SIRT1) and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) pathway drives the muscular fiber-type switching, and can directly regulate the biophysiological functions of skeletal muscle.
11p
viwashington2711
04-12-2019
9
1
Download
-
This paper discusses the continuous effect of the fractional order parameter of the Lu¨ system where the system response starts stable, passing by chaotic behavior then reaching periodic response as the fractional-order increases. In addition, this paper presents the concept of synchronization of different fractional order chaotic systems using active control technique. Four different synchronization cases are introduced based on the switching parameters. Also, the static and dynamic synchronizations can be obtained when the switching parameters are functions of time.
8p
kethamoi1
17-11-2019
19
0
Download
-
Dynamic power estimation is essential in designing VLSI circuits where many parameters are involved but the only circuit parameter that is related to the circuit operation is the nodes’ toggle rate. This paper discusses a deterministic and fast method to estimate the dynamic power consumption for CMOS combinational logic circuits using gate-level descriptions based on the Logic Pictures concept to obtain the circuit nodes’ toggle rate. The delay model for the logic gates is the real-delay model.
6p
kequaidan1
16-11-2019
25
0
Download
-
Rac1, known as a “molecular switch”, plays a crucial role in plenty of cellular processes. Rac1 aggravates the damage of myocardial cells in the process of myocardial ischemia-reperfusion during myocardial infarction through activating the NADPH oxidase and bringing about the reactive oxygen species(ROS) generation.
10p
vihasaki2711
12-11-2019
17
1
Download
-
This paper introduces a control structure based on the classical PID controller in order to monitor the IGBT switching frequency while still guaranteeing the qualities of SAPF. There are two controlled loops needed for the system.
10p
visumika2711
17-07-2019
14
0
Download
-
Lecture VLSI Digital signal processing systems - Chapter 17: Low-power design includes content as: VLSI digital signal processing systems, power consumption in DSP, power dissipation, CMOS power consumption, dynamic power consumption, switching activity (α), increased switching activity due to glitching,…
34p
shiwo_ding6
31-05-2019
59
1
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)