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Synthetic peptide
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Ebook "The chemistry of benzotriazole derivatives: A tribute to Alan Roy Katritzky" provides readers with contents including: preparation, reactivity, and synthetic utility of simple benzotriazole derivatives; benzotriazole-based strategies toward peptidomimetics, conjugates, and other peptide derivatives; benzotriazole-mediated synthesis of oxygen-containing heterocycles; benzotriazole-mediated synthesis of nitrogen-containing heterocycles;...
298p
tracanhphuonghoa1007
22-04-2024
3
3
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Ebook "Designing receptors for the next generation of biosensors" shows how synthetic receptors can be designed with characteristics that make them attractive alternatives to biological molecules in the sensory and diagnostics fields, with contributions from leading experts in the area.
271p
coduathanh1122
27-03-2024
3
1
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Ebook "Prokaryotic antimicrobial peptides: From genes to applications" will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book.
451p
manmanthanhla0201
26-02-2024
3
1
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Ebook "Cyclic peptides: From bioorganic synthesis to applications" introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial.
391p
lucchinguyen
28-12-2023
7
2
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Southern rice black-streaked dwarf virus (SRBSDV) causes severe epidemical disease on rice with the infected area up to millions of hectares in South China and North and Central of Vietnam. So far, there are no effective, cheap, quick, and practicable methods for diagnosing SRBSDV. The conventional RT-PCR technique is the most popular method for detecting SRBSDV with high accuracy.
9p
viengels
25-08-2023
2
2
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The aim of this work was to expand the applicability range of UHPSFC to series of synthetic and commercialized peptides. Initially, a screening of different column chemistries available for UHPSFC analysis was performed, in combination with additives of either basic or acidic nature.
12p
viginny
23-12-2022
8
2
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The aim of this study was to evaluate the potential of ultra-high performance supercritical fluid chromatography (UHPSFC) for peptide analysis by comparing its analytical performance to several chromatographic approaches based on reversed-phase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC) and mixed-mode liquid chromatography.
11p
vironald
15-12-2022
6
2
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Inhalation of TIP peptides that mimic the lectin-like domain of TNF-α is a novel approach to attenuate pulmonary oedema on the threshold to clinical application. A placebo-controlled porcine model of acute respiratory distress syndrome (ARDS) demonstrated a reduced thermodilution-derived extravascular lung water index (EVLWI) and improved gas exchange through TIP peptide inhalation within three hours.
8p
viisaacnewton
26-04-2022
9
1
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Lactoferricin (Lfcin) is an antimicrobial activity center of lactoferrin, produced by hydrolysis from the N-terminal of lactoferrin. It was hypothesized that the intramolecular disulfide bond in Lfcin could affect its antibacterial function through influencing its molecular structure.
10p
vigandhi
23-02-2022
10
1
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Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the swine industry globally. Evaluation of antibody responses and neutralizing antibody titers is the most effective method for vaccine evaluation.
12p
vidarwin
22-02-2022
11
1
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Prostaglandins and other eicosanoids are known as regulating agents for cellular immune responses to pathogen threats in an insect’s hemolymph. A novel synthetic peptide, WolFar, was customized from a conserved region of the Wolbachia surface protein (WSP), isolated from an economically important endoparasitoid species, Fopius arisanus. WolFar consists of nine amino acids (SYY VRL QYN) and was tested on the house cricket, Acheta domesticus. Three concentrations of peptides, 0.83 mmol/L (100%), 0.63 mmol/L (75%), and 0.42 mmol/L (50%), were injected and observed for 72 h.
10p
dolomite36
30-12-2021
9
0
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Brachystemin A (1) is a biologically active peptide from a Chinese traditional plant Brachystemma calycinum D. Don. (Caryophyllaceae). The current study describes the complete solid-phase total synthesis of peptide 1 by using Kenner’s sulfonamide safety-catch linker strategy. It was identified by QTOF/MS data and NMR studies. Synthetic peptide 1 was tested for its immunomodulatory effect on different inflammatory parameters, including production of inflammatory cytokines, interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and generation of nitric oxide (NO.).
18p
langthannam
29-12-2021
13
1
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Optimal functionality of synthetic lung surfactant for treatment of respiratory distress syndrome in preterm infants largely depends on the quality and quantity of the surfactant protein B (SP-B) peptide mimic and the lipid mixture.
12p
vimackenziebezos
29-11-2021
6
1
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Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mediated by T cells. The aim of the present study was to investigate the therapeutic efficacy of synthetic peptides (HP-R1, HP-R2 and HP-R3), derived from the sequence of 65-kD mycobacterial heat shock protein (HSP), in the treatment of RA using adjuvant-induced arthritis (AA) animal model.
7p
viannito2711
20-04-2021
7
1
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The lectin-like domain of TNF-α can be mimicked by synthetic TIP peptides and represents an innovative pharmacologic option to treat edematous respiratory failure. TIP inhalation was shown to reduce pulmonary edema and improve gas exchange.
11p
vimontana2711
05-04-2021
9
2
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High-accuracy mass spectrometry enables near comprehensive quantification of the components of the cellular proteomes, increasingly including their chemically modified variants. Likewise, large-scale libraries of quantified synthetic peptides are becoming available, enabling absolute quantification of chemically modified proteoforms, and therefore systems-level analyses of changes of their absolute abundance and stoichiometry.
7p
vioklahoma2711
19-11-2020
7
1
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Infectious Bursal Disease (IBD) is an economically important and contagious viral disease of poultry. An attempt was made for development of a synthetic peptide based diagnostic reagent. Cell culture adapted viral antigen was prepared by successful passage on CEF and then ultracentrifugation to get partially purified virus. Confirmation of the virus in was done by RT- PCR. The antigen was then used for the production of hyper immune sera in rabbits. Sera samples were also collected from known IBD vaccinated and non-vaccinated birds.
10p
trinhthamhodang1215
23-09-2020
11
0
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The present study aimed to design synthetic peptides as efflux pump inhibitors. Two synthetic peptides SG-15 and GG-15 were designed on the basis of protein sequence and structure of AcrAB-TolC a commonly expressed efflux pump of Escherichia coli (E. coli). SG-15 was designed as inner membrane protein (AcrB) blocker and GG-15 was designed as outer membrane protein (TolC) blocker. The designed inhibitors were custom synthesized.
10p
nguaconbaynhay7
15-08-2020
11
1
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Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T lymphocyte (CTL) responses in patients.
12p
vikuala271
13-06-2020
8
0
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NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘)i are essential for activating NS3 upon NS3/4A protease complex formation. This study aims to design new specific allosteric NS3/4A protease inhibitors by mutating Val-23‘, Ile-25‘, and Ile-29‘ into bulkier amino acids. Pep-15, a synthetic peptide, showed higher binding affinity towards HCV-NS3 subtype-4 than native NS4A. The Kd of Pep-15 (80.0 ± 8.0 nM) was twice as high as that of native NS4A (169 ± 37 nM).
9p
partimesinhvien
08-05-2020
15
1
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