Systems genetics

Prostate cancer is dependent on androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) has proven effective in targeting prostate cancer. However, castration-resistant prostate cancer (CRPC) eventually emerges. AR signaling inhibitors (ARSI) have been also used, but resistance to these agents develops due to genetic AR alterations and epigenetic dysregulation.

12p vishanshan 27-06-2024 1 1   Download

Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions.

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Acute myeloid leukemia (AML), characterized by the abnormal accumulation of immature marrow cells in the bone marrow, is a malignant tumor of the blood system. Currently, the pathogenesis of AML is not yet clear. Therefore, this study aims to explore the mechanisms underlying the development of AML.

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Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic risk factor for breast cancer, associated with poor prognostic factors. This study sought to explore the patterns and outcome of CNS metastases in breast cancer patients with germline PVs in BRCA1/2 genes.

12p vikoch 27-06-2024 1 1   Download

presents the following content: Chapter 1 introduction, chapter 2 approximation of a function, chapter 3 numerical calculus, chapter 4 ordinary differential equations, chapter 5 numerical methods for matrices, chapter 6 spectral analysis, chapter 7 partial differential equations, chapter 8 molecular dynamics simulations, chapter 9 modeling continuous systems, chapter 10 monte carlo simulations, chapter 11 genetic algorithm and programming, chapter 12 numerical renormalization.

402p zizaybay1103 29-05-2024 3 2   Download

The last decade has seen an explosion in our understanding of how bacterial pathogens trick, cajole, usurp and parasitize their various hosts. This renaissance is due to the convergence of molecular and cellular techniques with the power of microbial genetics. The purpose of this volume is to introduce recent advances in understanding selected systems chosen from both plant and animal hosts of bacterial pathogens.

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Ebook "Genome mapping and genomics in arthropods" provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. Insects and other arthropods, the largest group of animals in number of species, have global impact on agriculture, industry, human health and environment. They are of particular economic importance for food production as pollinators, for natural products like silk and also as pests and parasites.

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Ebook "Optimizing decision making in the apparel supply chain using artificial intelligence (AI): From production to retail" provides detailed coverage of these techniques, outlining how they are used to assist decision makers in tackling key supply chain problems.

245p dongmelo 26-05-2024 3 2   Download

Ebook "Genetic diversity and variability of hepatitis B virus (HBV)" provides readers with contents including: Chapter 1 - Introduction; Chapter 2 - HBV epidemiology in Latin America and the Caribbean (LAC) region; Chapter 3 - HBV variants and mutants and its Impact on the LAC region; Chapter 4 - Conclusions;...

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Part 1 book "Robbins basic pathology" includes content: The cell as a unit of health and disease; cell injury, cell death, and adaptations; inflammation and repair; hemodynamic disorders, thromboembolism, and shock; diseases of the immune system; neoplasia; genetic and pediatric diseases; environmental and nutritional diseases.

405p zizaybay1101 30-04-2024 2 2   Download

Part 2 book "A textbook of opthalmology" includes content: Ocular diseases and ocular affections in systemic diseases - urgical procedures, miscellaneous aspects, genetics and paediatric ophthalmology, immunology related to ocular disorders, prevention and rehabilitation of blindness.

363p zizaybay1101 30-04-2024 6 3   Download

Ebook "Genetics meets metabolomics: From experiment to systems biology" is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

328p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Genetic transformation systems in fungi (Volume 1)" will cover the basics behind the most commonly used transformation methods, as well as associated tools and techniques. Each chapter will provide protocols along with examples used in laboratories worldwide.

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Ebook "Longevity genes: A blueprint for aging" describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

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Ebook "Systems biology of RNA binding proteins" provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.

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Ebook "Biology of inositols and phosphoinositides: Subcellular biochemistry (Volume 39)" describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward.

348p tracanhphuonghoa1007 22-04-2024 4 1   Download

Ebook "Alginates: Biology and applications" provides an overview of the state of art of alginate material properties, genetics and the molecular mechanisms underlying alginate biosynthesis as well as applications of tailor-made alginates in medicine, food and biotechnology. Topics treated are: material properties of alginates, alginate production: precursor biosynthesis, polymerization and secretion, bacterial system for alginate uptake and degradation, enzymatic alginate modification,...

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Ebook "Sensing in nature" is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature. The presentation in this book lies at the intersection of evolutionary biology, cell and molecular biology, physiology and genetics. Sensing in Nature is written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community.

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Ebook "BetaSys: Systems biology of regulated exocytosis in pancreatic β-cells" gives a snapshot of the field at the threshold of a possible explosion in knowledge. We introduce recent advances in observational techniques, ranging from genetic epidemiology via proteomics to multi-parameter cell sensoring, MRI, ET and nanoparticle-based cell imaging.

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Ebook "Self and nonself" focuses on the origin of the immune response during the development of multicellularity (Chapters 1-4). Bacteria have developed defense systems against viruses and conversely, viruses have devised escape mechanisms that allow infection. Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity known as the CRISPR-Cas, that confers resistance to mobile genetic elements.

338p tracanhphuonghoa1007 22-04-2024 1 1   Download