T cell immune response
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Although HPV prophylactic vaccines can provide effective immune protection against high-risk HPV infection, studies have shown that the protective effect provided by them would decrease with the increased age of vaccination, and they are not recommended for those who are not in the appropriate age range for vaccination.
11p vikoch 27-06-2024 1 1 Download
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Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction.
14p vibransone 28-03-2024 7 2 Download
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Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process.
14p vibransone 28-03-2024 2 1 Download
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Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers evaluated for clinical management of cancer patients across histologies.
18p vibransone 28-03-2024 6 1 Download
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Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM).
11p vibransone 28-03-2024 2 2 Download
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p vibransone 28-03-2024 6 2 Download
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T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress will improve the efficacy of immunotherapy.
16p vibransone 28-03-2024 3 2 Download
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Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors.
13p vibransone 28-03-2024 8 2 Download
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The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate immunosuppression.
19p vibransone 28-03-2024 3 2 Download
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Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated immune responses against tumor, resulting in improved overall survival in cancer patients. It has emerged that the intestinal microbiome can modulate responses to ICIs via the host immune system and that the use of antibiotics can lead to reduced efficacy of ICIs.
11p vibransone 28-03-2024 4 2 Download
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Tumor response to therapy is affected by both the cell types and the cell states present in the tumor microenvironment. This is true for many cancer treatments, including immune checkpoint inhibitors (ICIs). While it is well-established that ICIs promote T cell activation, their broader impact on other intratumoral immune cells is unclear; this information is needed to identify new mechanisms of action and improve ICI efficacy.
22p vibransone 28-03-2024 3 1 Download
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A limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods: Herein, we performed comprehensive molecular characterization of immediate (D-42 to D-1) pretreatment tumor biopsy specimens from 60 patients with sorafenib-failed HCC in a single-arm prospective phase II trial of pembrolizumab.
15p vibransone 28-03-2024 4 2 Download
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p vicwell 29-02-2024 3 1 Download
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Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection.
24p vicwell 29-02-2024 1 1 Download
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Part 1 book "Cancer immunology and immunotherapy" includes content: Immune infiltration in human cancer - prognostic significance and disease control, subversion and coercion - the art of redirecting tumor immune surveillance, a target to enhance antitumor immune response, biology and clinical observations of regulatory T-cells in cancer immunology, concepts and ways to amplify the antitumor immune response, angiogenesis and the tumor vasculature as antitumor immune modulators - The role of vascular endothelial growth factor and endothelin.
163p muasambanhan08 23-02-2024 6 1 Download
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Ebook "The biology of dendritic cells and HIV infection" focuses on the role of DCs in the pathogenesis and immunity of HIV-1 infection. It has recently been clarified that DCs are important targets and reservoirs of HIV and may play an important role in virus spreading to T cells. Interestingly, HIV can exploit many of the cellular processes responsible for the generation and regulation of the adaptive immune responses to gain access to its main target cells, i.e. the CD4+ T lymphocytes.
562p tachieuhoa 28-01-2024 3 2 Download
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Part 1 book "Veterinary immunology" includes content: Surviving in a microbial world; innate immunity; humoral innate immunity; humoral innate immunity; cellular innate immunity; cellular innate immunity; sickness; how immune cells communicate; antigens; dendritic cells and antigen processing; the major histocompatibility complex; organs of the immune system; lymphocytes; helper t-cells and their response to antigens; b-cells and their response to antigens; antibodies.
504p muasambanhan03 02-01-2024 9 2 Download
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Part 1 book "Veterinary immunology" includes content: The defense of the body, innate immunity, innate immunity, innate immunity, innate immunity, systemic responses to inflammation; innate immunity; cell signaling; antigens; dendritic cells and antigen processing; the major histocompatibility complex; organs of the immune system; lymphocytes; helper t'cells and their response to antigen; b'cells and their response to antigen 16 antibodies; how antigen binding receptors are made,... and other contents.
324p muasambanhan03 02-01-2024 2 2 Download
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Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 in colorectal cancer (CRC) remains unclear. The antigen presentation and antitumor immune effects of galectin-9 in CRC were examined in this study.
11p vileonardodavinci 23-12-2023 2 2 Download
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Biomarkers that can accurately predict the efcacy of immune checkpoint inhibitors (ICIs) against programmed death 1 (PD-1) ligand in cancer immunotherapy are urgently needed. We have previously reported a novel formula that predicts the response to treatment with second-line nivolumab with high sensitivity and specificity in patients with non-small cell lung cancer (NSCLC) previously treated with chemotherapy.
10p vileonardodavinci 23-12-2023 6 3 Download