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T cell subsets
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Ebook "T helper cell differentiation and their function" will focus on the differentiation and regulation of subsets of CD4+ T cells. It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets’ plasticity and their role in healthy and disease conditions. The book provides researchers and graduate students with a cutting-edge and comprehensive overview of essential research on CD4+ T cells.
237p
tracanhphuonghoa1007
22-04-2024
4
1
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For at least 300 years the immune system has been targeted to improve human health. Decades of work advancing immunotherapies against infection and autoimmunity paved the way for the current explosion in cancer immunotherapies.
10p
vibransone
28-03-2024
2
1
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Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-memory (TEM), central memory (TCM), or terminal effector (TEMRA) subsets in blood and tissues.
14p
vibransone
28-03-2024
5
1
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Part 2 book "Cancer immunology and immunotherapy" includes content: Adoptive cellular therapy, dendritic cell subsets as vectors and targets for improved cancer therapy, identification of human idiotype specific T-cells in lymphoma and myeloma, immunologically active biomaterials for cancer therapy,... and other contents.
156p
muasambanhan08
23-02-2024
11
1
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There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a high frequency of circulating CD4+FoxP3+ Tregs was associated with poorer disease-free survival (DFS), while their higher frequencies in tumour-infltrating CD4+ Tregs was associated with better DFS.
13p
visusanwojcicki
28-06-2022
7
2
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Despite increasing interest in γδ T cells and their non-classical behaviour, most studies focus on animals with low numbers of circulating γδ T cells, such as mice and humans. Arguably, γδ T cell functions might be more prominent in chickens where these cells form a higher proportion of the circulatory T cell compartment. The TCR repertoire defines different subsets of γδ T cells, and such analysis is facilitated by well-annotated TCR loci. γδ T cells are considered at the cusp of innate and adaptive immunity but most functions have been identified in γδ low species.
19p
vilarryellison
29-10-2021
8
1
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In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value using an immunohistochemical staining method.
10p
vianrose2711
27-04-2021
15
2
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The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood. Methods: We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry.
9p
vioregon2711
22-02-2021
10
2
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Host immune response is coordinated by a variety of different specialized cell types that vary in time and location. While host immune response can be studied using conventional low-dimensional approaches, advances in transcriptomics analysis may provide a less biased view.
15p
vicolorado2711
23-10-2020
14
0
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Shifts in CD8+ T-cell subsets that are hallmarks of immunosenescence are observed in ageing and in conditions of chronic immune stimulation. Presently, there is limited documentation of such changes in lung cancer and other malignancies affecting the lungs.
11p
vinaypyidaw2711
26-08-2020
11
2
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Hepatitis C virus (HCV) infects many people worldwide and it is a leading cause of cirrhosis and hepatocellular carcinoma. Natural Killer (NK) cells have an important role during HCV infection as a part of innate immune responses. Three subtypes of NK cells are recognized: CD56dim CD16+ve, CD56bright CD16+ve and CD56–veCD16+ve. Natural killers T (NKT) (CD3CD16CD56+ve) cells are subsets of T lymphocytes that help in innate immune response because they can be directly cytotoxic.
13p
chauchaungayxua6
26-06-2020
21
1
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Bursa of Fabricius, the primary lymphoid organ for B-lymphopoiesis in Avian species and is responsible for humoral immunity. Flow cytometric analysis of Bu-1a+ B-cell count and CD3+, CD4+ and CD8+ T-cell count were conducted in bursa of Fabricius of four different age groups of Nandanam broiler chicken viz., day-old, two, four and six weeks. Twelve birds from each age group, from both vaccinated and non-vaccinated groups were utilised. Tissue samples of the bursa were collected aseptically and processed for flow cytometric studies using monoclonal antibodies.
6p
nguaconbaynhay6
24-06-2020
10
0
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Flowcytometric analysis of T lymphocyte subset viz., CD and CD8 cells in spleen and thymus was done in Nandanam layer chicken of different age groups ranging from day-old to forty weeks. . In spleen, the mean CD4 and CD8 population was found to be the highest at day one and lowest at twenty weeks of age. However, an increase in both the T cell population was detected at forty weeks.
5p
nguaconbaynhay6
23-06-2020
9
0
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Age-related genetic changes in lymphocyte subsets are not currently well documented. BACH2 is a transcription factor that plays an important role in immune-mediated homeostasis by tightly regulating PRDM1 expression in both B-cells and T-cells. BACH2 gene expression is highly sensitive to DNA damage in aged mice.
10p
viputrajaya2711
22-06-2020
8
0
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Tumor-infiltrating lymphocytes (TILs) play a critical role in tumor immune surveillance and immune suppression. Understanding tumor infiltrating T cell subset density, location and PD-1/PD-L1 expression might provide insight for the prediction of tumor therapeutic response and clinical outcome.
11p
vikuala271
13-06-2020
14
0
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In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical outcome.
9p
vikuala271
13-06-2020
16
0
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Human immunological memory is a hallmark of the adaptive immune system and plays an important role in the development of effective immune responses against tumors. In the present study, we aimed to determine the frequencies of CD8+ memory T cell subsets including T stem cell memory (TSCM) in tumor-draining lymph nodes of patients with breast cancer (BC).
9p
vijakarta2711
09-06-2020
17
1
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Kawasaki disease (KD) is an acute febrile vasculitis that primarily affects children. Previous studies have shown that both innate and adapt immune systems are involved in the immunopathogenesis of KD.
9p
vidublin2711
13-01-2020
9
1
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Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis
Sarcoidosis is a systemic inflammatory disorder characterized by granulomas. Not enough evidences correlate the derangement of CD4+ T subsets, which have an impact on the therapeutic effects of corticosteroids, with the radiographical staging of sarcoidosis. Here we show the disturbance of CD4+ T subsets in newly diagnosed stage II pulmonary sarcoidosis, which is the most common stage in which corticosteroids treatment is used.
7p
vicaracas2711
27-11-2019
9
1
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Anovel caspase-like activity, which is directly regulatedwith cell proliferation is a candidate to regulate the abundance of the cyclin-dependent kinase inhibitor, p27 KIP1 , in human lymphoid cells.This activity, whichwe termKIPase activity, can also cleave a subset of caspase substrates.Here we demonstrate thatKIPase is anovel enzymedistinct fromany of the previously characterized human caspases.
8p
dell39
03-04-2013
38
2
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