Báo cáo khoa học: KIPase activity is a novel caspase-like activity associated with cell proliferation

Anovel caspase-like activity, which is directly regulatedwith cell proliferation is a candidate to regulate the abundance of the cyclin-dependent kinase inhibitor, p27 KIP1 , in human lymphoid cells.This activity, whichwe termKIPase activity, can also cleave a subset of caspase substrates.Here we demonstrate thatKIPase is anovel enzymedistinct fromany of the previously characterized human caspases.We show thatKIPase is active in a variety of cell lineages, its activity is associated with the proliferation of the human T-cell line, Jurkat, and is not inhibited by the broad spectrum caspase inhibitor z-VAD-fmk....