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TCA cycle
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Recent advances in metabolomics have enabled larger proportions of the human metabolome to be analyzed quantitatively. However, this usually requires the use of several chromatographic methods coupled to mass spectrometry to cover the wide range of polarity, acidity/basicity and concentration of metabolites.
11p
viginny
23-12-2022
9
4
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Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC are still unclear.
17p
vimahuateng
26-11-2021
8
2
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Human requirements for dietary selenium are met mainly by crops. However, excessive uptake of selenium in plants can restrict growth, and its toxicity has been postulated to target roots.
15p
viminato2711
22-05-2020
15
0
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The tricarboxylic acid (TCA) cycle is crucial for cellular energy metabolism and carbon skeleton supply. However, the detailed functions of the maize TCA cycle genes remain unclear.
16p
viharuno2711
21-04-2020
13
2
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(BQ) Part 1 of the document Lippincott's illustrated Q&A review of biochemistry presents the following contents: TCA cycle and oxidative phosphorylation, glycogen metabolism, fatty acid metabolism, HMP shunt and oxidative reactions, amino acid metabolism and the urea cycle, phospholipid metabolism,...
94p
thangnamvoiva3
28-06-2016
71
6
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Learning objectives of this chapter include: Know the overall reaction of the citric acid cycle, know the names of the intermediates of the TCA cycle from pyruvate to OAA, know the name of the enzymes involved in each step, know the co-factors involved in each step of the TCA cycle, know what co-factors are required by pyruvate dehydrogenase and beable to describe what their function is in the conversion of pyruvate to acetyl-CoA.
32p
tangtuy02
08-03-2016
60
5
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In this chapter you will know that it is a way that some organism can use acetyl-CoA to synthesize carbohydrates. Know why organisms without this pathway can not do this. Know where malate synthase and isocitrate lyase by-pass the decarboxylation steps of TCA. Be able to recognize the intermediates of the glyoxlate cycle and know where they fit into the TCA cycle and where they feed into gluconeogenesis,...
14p
tangtuy02
08-03-2016
42
2
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Isocitrate dehydrogenase (IDH) catalyzes the reversible conversion between isocitrate and 2-oxoglutarate accom-panied by decarboxylation/carboxylation and oxidoreduc-tion of NAD(P) + cofactor.While this enzyme has beenwell studiedas a catabolic enzyme in the tricarboxylicacid (TCA) cycle, here we have characterized NADP-dependent IDH fromChlorobiumlimicola, agreen sulfur bacteriumthat ®xes CO2 through the reductive tricarboxylic acid (RTCA) cycle, focusing on theCO2-®xation ability of the enzyme. ...
6p
research12
23-04-2013
42
1
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Erythrocytic stages of the malaria parasitePlasmodium fal-ciparumrely on glycolysis for their energy supply and it is unclear whether they obtain energy via mitochondrial res-piration albeit enzymes of the tricarboxylic acid (TCA) cycle appear to be expressed in these parasite stages. Isocitrate dehydrogenase (ICDH) is either an integral part of the mitochondrial TCA cycle or is involved in providing NADPH for reductive reactions in the cell.
9p
fptmusic
16-04-2013
50
1
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