Telomeric repeat
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The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited proliferation by reactivating the reverse transcriptase telomerase or by using the alternative lengthening of telomeres (ALT) pathway.
10p vinarcissa 21-03-2023 2 1 Download
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Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying the effects of advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) represents a type of long noncoding RNA.
15p vimaine2711 26-03-2021 7 2 Download
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The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular processes such as DNA replication and transcription. These DNA adducts can effectively induce cancer cell death, however, there are a range of clinical side effects and drug resistance issues associated with its use.
17p vinaypyidaw2711 26-08-2020 16 1 Download
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Telomere comprises of TTAGGG repeats and its lack of functionality results in promoting cancer through driving genetic instability. It is evident that they protect chromosomal ends and conserve our genetic information. This review discusses various laboratory methods of telomere length measurement.
6p nguaconbaynhay7 15-08-2020 6 0 Download
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Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such as DNA replication and transcription.
16p viputrajaya2711 22-06-2020 10 2 Download
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Short strands of tandem hexameric repeats known as telomeres cap the ends of linear chromosomes.These repeats protect chromosomes from degradation and prevent chro-mosomal end-joining, a phenomenon that could occur due to the end-replicationproblem.Telomeres aremaintainedby the activity of the enzyme telomerase.The total number of telomeric repeats at the terminal end of a chromosome determines the telomere length, which in addition to its importance in chromosomal stabilization is a useful indica-tor of telomerase activity in normal and malignant tissues....
15p tumor12 20-04-2013 32 2 Download
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The chromosomal ends ofLeishmania (Leishmania) ama-zonensis contain conserved 5¢-TTAGGG-3¢ telomeric repeats. Protein complexes that associatein vitro with these DNA sequences,Leishmania amazonensisG-strand telo-meric protein (LaGT1-3), were identified and characterized byelectrophoreticmobilityshift assays andUVcross-linking using protein fractions purified from S100 and nuclear extracts.
14p awards 05-04-2013 35 3 Download
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The 3¢-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1.
9p mobifone23 18-01-2013 39 3 Download
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Long telomeres in the polytene chromosomes of Drosophila melanogaster are associated with amplification of subtelomeric repeat sequences
0p toshiba20 12-11-2011 47 2 Download
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Telomerase DNA polymerase is unable to replicate the tips of chromosomes, resulting in the loss of DNA at the specialized ends of chromosomes (called telomeres) with each replication cycle. At birth, human telomeres are 15- to 20-kb pairs long and are composed of tandem repeats of a six-nucleotide sequence (TTAGGG) that associate with specialized telomere-binding proteins to form a T-loop structure that protects the ends of chromosomes from being mistakenly recognized as damaged.
5p konheokonmummim 03-12-2010 75 6 Download