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Tetracyclic antidepressants

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  • Introduction: Many of antidepressants exert their effects by inhibiting the reuptake of norepinephrine and serotonin and by accerelating the release of them at synaptic terminals of neurons in the brain. As characteristic structures of such drugs showing antidepressive effects, many of them have tricyclic or tetracyclic nuclei; this is the reason why they are called “tricyclic antidepressants or tetracyclic antidepressants”. There are many cases of suicides using the antidepressants; their massive intake sometimes causes death.

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